Documentation scienceplus.abes.fr version Bêta

À propos de : A Concise Synthesis of Lentiginosine DerivativesUsing a Pyridinium Formation via the MitsunobuReaction        

AttributsValeurs
type
Is Part Of
Subject
Title
  • A Concise Synthesis of Lentiginosine DerivativesUsing a Pyridinium Formation via the MitsunobuReaction
has manifestation of work
related by
Author
Abstract
  • A four-step synthesis of (−)-lentiginosine and its epimers isdescribed starting from 2-bromopyridine. The key stepconsisted of a quaternarization of a fully unprotectedpyridinium-polyol unit using Mitsunobu methodology. Subsequent PtO2-catalyzed diastereoselective hydrogenation ofthe pyridinium ring proceeded smoothly and led to theexpected dihydroxyindolizidines with excellent yields. Thisstereochemically flexible strategy has been illustrated by theconcise total synthesis of non-natural products derivativessuch as (−)-lentiginosine and its stereoisomers in high yields.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata