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À propos de : One-Pot Synthesis of 3-Fluoro-4-(trifluoromethyl)quinolines fromPentafluoropropen-2-ol and Their Molecular Modification        

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  • One-Pot Synthesis of 3-Fluoro-4-(trifluoromethyl)quinolines fromPentafluoropropen-2-ol and Their Molecular Modification
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  • Pentafluoropropen-2-ol (PFP) was prepared by the reaction of hexafluoroacetone (HFA) with Mg/TMSCl.The one-pot tandem sequential reactions of PFP via Mannich addition with aldimines followed by Friedel−Crafts cyclization and aromatization afforded the title quinolines. A variety of corresponding 3-substitutedquinolines were derived from the title quinoline by nucleophilic substitution of 3-fluorine with nucleophiles.A defluorinative transformation of the 4-trifluoromethyl group of the title quinoline with hydrazine affordedpyrazoloquinoline.
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