Highly Diastereoselective Addition of the LithiumEnolate of α-Diazoacetoacetate to N-SulfinylImines: Enantioselective Synthesis of 2-Oxo and3-Oxo Pyrrolidines
The highly enantioselective synthesis of 2-oxo and 3-oxopyrrolidines has been achieved by diastereoselective additionof the lithium enolate of α-diazoacetoacetate to chiralN-sulfinyl imines, followed by photoinduced Wolff rearrangement or Rh(II)-catalyzed intramolecular N−H insertion.