| Abstract
| - The thermal and electron-impact (EI) stabilities of eight 3,6-disubstituted-1,2,4,5-tetrazines were examined.Major EI peaks were also investigated by tandem mass techniques to construct fragmentation pathways.Tetrazine ring structures were not maintained under electron impact ionization nor under conditions of thermaldecomposition. Under electron impact, the tetrazines examined shared the same initial fragmentationpathways: elimination of two of the nitrogen atoms as N2 from the tetrazine ring and cleavage of the remainingN−N bond. This pathway was also applicable to thermal decomposition; however, the main route involveddissociation of the substituent group, in some cases assisted by proton transfer.
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