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À propos de : Hydrogen-Bond Accepting Strength of Protonated Nicotine        

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  • Hydrogen-Bond Accepting Strength of Protonated Nicotine
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  • Recent crystal structures of nicotine bound to the acetylcholine binding protein (AChBP) ended a long debateconfirming that the pyridine nitrogen of nicotine is indeed hydrogen-bonded to receptor residues through abridging water molecule. Here, we describe the first direct experimental evaluation of the hydrogen-bondaffinity of the nicotinium pyridine nitrogen. The equilibrium constant of its association with a phenol is 1order of magnitude greater than the association of the acetylcholine carbonyl oxygen.
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