| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| Title
| - Development of a Biologically Relevant Calcium Phosphate Substrate for Sum FrequencyGeneration Vibrational Spectroscopy
|
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - A novel biologically relevant composite substrate has been prepared consisting of a calcium phosphate (CaP)layer formed by magnetron sputter-coating from a hydroxyapatite (HA) target onto a gold-coated siliconsubstrate. The CaP layer is intended to mimic tooth and bone surfaces and allows polymers used in oral careto be deposited in a procedure analogous to that used for dental surfaces. The polymer cetyl dimethiconecopolyol (CDC) was deposited onto the CaP surface of the substrate by Langmuir Blodgett deposition, andthe structure of the adsorbed layer was investigated by the surface specific technique of sum frequencygeneration (SFG) vibrational spectroscopy. The gold sublayer provides enhancement of the SFG signal arisingfrom the polymer but plays no part in the adsorption of the polymer. The surface morphology of the substratewas investigated using SEM and AFM. The surface roughness was commensurate with that of the thermallyevaporated gold sublayer and uniform over areas of at least 36 μm2. The chemical composition of the CaP-coated surface was determined by FTIR and TOF-SIMS. It was concluded that the surface is primarily calciumphosphate present as a mixture of amorphous, non-hydroxylated phases rather than solely stoichiometrichydroxyapatite. The SFG spectra from CDC on CaP were closely similar, both in resonance wavenumbersand in their relative intensities, with spectra of thin films of CDC recorded directly on gold. Application ofprevious analysis of the spectra of CDC on gold therefore enabled interpretation of the polymer orientationand conformation on the CaP substrate.
|
| article type
| |
| is part of this journal
| |
