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| - Combining Small Angle Neutron Scattering (SANS) and Fluorescence CorrelationSpectroscopy (FCS) Measurements To Relate Diffusion in Agarose Gels to Structure
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| - Small angle neutron scattering (SANS) and fluorescence correlation spectroscopy (FCS) measurements werecarried out on agarose hydrogels to link their microscopic structure to the diffusivity of solutes at differentscales. SANS allowed for the determination of the distribution of void volumes within the gels. They wereshown to be compatible with a random network of cylindrical fibers as described by the Ogston model. FCSmeasured solute diffusivity in spaces similar in size to the void volumes, and thus, the results reflected thegel heterogeneity. Solute diffusivity was predicted by modeling the gel as microscopic geometrical cells.Variations in the diffusivity of solutes of different sizes could be predicted from the structural parameters ofthe gel using theory, taking into account obstruction by cylindrical cells and solute hydrodynamics. Predictionof the FCS autocorrelation functions for solutes from a cell model demonstrated a lack of sensitivity of thistechnique for multicomponent analysis.
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