| Abstract
| - The synthesis on a solid support of a dodecapeptide containing aHAV-VP2 exposed sequence is described.The surface activity of this peptide as well as its miscibilityand interactions with dipalmitoylphosphatidylcholine (DPPC), dipalmitoylphosphatidylethanolamine (DPPE), andphosphatidylinositol (PI) weredetermined. Interaction energies calculated applying the Gibbsequation gave very small values, thussuggesting either ideal miscibility or weak interactions. In allcases the electrical charge in DPPE andPI monolayers seems to create a high electrostatic potential,decreasing its interaction with any externalmolecule. This peptide was able to accommodate a certain amount ofanilinonaphthalenesulfonate molecules,showing an intermediate hydrophobic character. Moreover, afterincubation with saturated liposomes,the peptide showed a clear rigidifying effect at the level of polarheads, especially at temperatures underthe transition temperature.
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