| Abstract
| - Monoolein (GMO) forms a bicontinuous cubic phase that can coexist in equilibrium with a water phase,and this phase can be dispersed into colloidal particles. Poloxamer is an efficient stabilizer for dispersionsof this phase. By adding a small amount of triolein to GMO, a reversed hexagonal phase is formed at roomtemperature. This phase can be dispersed into submicron particles in water in the same way. The innermolecular arrangement of these dispersions was investigated by 13C NMR relaxation. The 13C NMR relaxationrates of the various GMO carbon atoms obtained from the dispersed particles compared to those obtainedfrom the nondispersed phases indicate that the lipid organization and dynamic properties of the originalnondispersed phases are retained. It is also demonstrated that the cubic phase is transformed into thereversed hexagonal phase, within six months, due to hydrolysis of GMO. A remarkable observation is thatno significant hydrolysis occurs during this time in the corresponding dispersed samples. This indicatesthat solubilization of a few wt % of Poloxamer into the GMO bilayer provides protection against degradation.
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