| Abstract
| - Dependence of the concentration of peptide antibiotics on the lysis of liposomes of different compositionsis presented in this study. Here, we clearly demonstrate that cecropin B and its analogues can lyse anionicliposomes immobilized on a biosensor chip. Surface plasmon resonance measurements showed that, fortwo peptides, lysis was only induced at low peptide concentrations and, at higher concentrations, thepeptides bound to the liposomes without lysing them. The concentration-dependent mechanism of peptide−lipid interactions revealed here is relevant to the action of cationic peptides on the anionic membranesof bacteria and neoplastic cells. Use of the technique described here will provide a new direction to assessthe action and efficacy of antibacterial peptides, antibiotics, and anticancer agents.
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