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| - Surface Properties, Fibrinogen Adsorption, and CellularInteractions of a Novel Phosphorylcholine-ContainingSelf-Assembled Monolayer on Gold
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| - A novel synthetic route for the preparation of a phosphorylcholine terminated thiol is presented. Thenew molecule was characterized by FTIR and NMR and was used to prepare one- and two-componentmonolayers rich in phosphorylcholine. The new surfaces had an intermediate hydrophilicity based on theirsessile contact angles, but dynamic contact angle measurements showed that the surfaces became completelywettable when in contact with water. Ellipsometric measurements revealed that the molecules extendedtoward the monolayer−air interface similar to well-studied monolayers prepared from methyl- or hydroxyl-terminated thiols. Angle-resolved XPS survey measurements verified that phosphorus, nitrogen, and oxygenwere situated closer to the monolayer−air interface, a conclusion also supported by angle-resolved C 1smeasurements. Grazing-angle FTIR data indicated a less ordered structure for all the PC-containingmonolayers than that of a methyl-terminated SAM. Fibrinogen adsorption and neutrophil adhesion on thenew surfaces were significantly lower than on gold and on CH3-terminated SAMs. Bacterial adhesion wasnot found to vary significantly between the surfaces examined.
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