| Abstract
| - This study introduces a new approach for producing highly monosized polymer microcapsules. Thetechnique employs an impressive process in which the solute, dissolved freely in a solvent, is diffuseduniformly into the preexisting monosized polymer particles in the form of a fine emulsion. The solvent isthen eliminated, resulting consequently in solute-loaded polymer microcapsules. We named it a soluteco-diffusion method, SCM. The loading efficiency of the solute was predicted successfully by a thermodynamicequation. In the experiment, the indomethacin-loaded poly(methyl methacrylate) microparticles wereproduced via SCM. From our results, SCM is expected to expand significantly the drug-loading technologyin related fields.
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