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| - Formation of a Supported Hybrid Bilayer Membrane onGold: A Sterically Enhanced Hydrophobic Effect
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| - Adsorption of a monolayer of didecanoyl-l-α-phosphatidylcholine (DDPC) from dispersions of smallunilamellar vesicles onto hydrophobic surfaces was investigated by means of cyclic voltammetry andimpedance spectroscopy. The hydrophobic surfaces were self-assembled monolayers of 2-mercapto-3-n-octylthiophene (MOT) on gold. One characteristic of the MOT monolayer is its permeability to organicmolecules in aqueous solution, thus providing a more energetically favorable hydrophobic surface for theaddition of phospholipid vesicles. The kinetics of the lipid monolayer formation were followed by measuringthe time-dependent interfacial capacitance. Unusual values of thickness and capacitance of the MOT/DDPC bilayers were observed. An interdigitating conformation of the bilayer structure was proposed tointerpret the experimental results. The horseradish peroxidase reconstituted into the bilayer demonstratedthe expected protein activity, showing practical use in research and in biosensor application.
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