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À propos de : Fabrication of Gradient Hydrogels Using a Microfluidics/Photopolymerization Process        

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  • Fabrication of Gradient Hydrogels Using a Microfluidics/Photopolymerization Process
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  • A method of fabricating photo-cross-linked hydrogels with gradients of immobilized molecules and cross-linking densities is introduced. Two macromer/initiator solutions are injected into a unique poly(dimethylsiloxane) channel system that produces a prepolymer gradient that is subsequently polymerizedinto a water-swollen hydrogel with ultraviolet light exposure. The gradient is controlled by the injectionflow rate (optimized to 0.3 μL/min per inlet to produce a linear gradient). The technique is investigatedboth through fabrication of adhesive ligand gradients that modulate spatial distribution of attachedendothelial cells and gradients of cross-linking densities that led to unique hydrogel architectures andspatially dependent swelling.
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