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| - Protein-Resistant Polymer Coatings on Silicon Oxide bySurface-Initiated Atom Transfer Radical Polymerization
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| - The modification of silicon oxide with poly(ethylene glycol) to effectively eliminate protein adsorption has provento be technically challenging. In this paper, we demonstrate that surface-initiated atom transfer radical polymerization(SI-ATRP) of oligo(ethylene glycol) methyl methacrylate (OEGMA) successfully produces polymer coatings onsilicon oxide that have excellent protein resistance in a biological milieu. The level of serum adsorption on thesecoatings is below the detection limit of ellipsometry. We also demonstrate a new soft lithography method via whichSI-ATRP is integrated with microcontact printing to create micropatterns of poly(OEGMA) on glass that can spatiallydirect the adsorption of proteins on the bare regions of the substrate. This ensemble of methods will be useful inscreening biological interactions where nonspecific binding must be suppressed to discern low probability bindingevents from a complex mixture and to pattern anchorage-dependent cells on glass and silicon oxide.
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