| Abstract
| - As part of a program evaluating homochiral and heterochiral amino- and carboxylic acid-substituted γ-lactams as conformationally constrained dipeptide building blocks, we have synthesizedby the solid-phase technique and assessed by X-ray diffraction the crystal-state structure of the terminallyblocked homotrimer from (2S,4R)-4-amino-5-oxopyrrolidine-2-carboxylic acid, characterized by a unique,alternating cis−trans amide sequence. Using computer modeling, we also showed that the rigidconformation of the trimer can be exploited as a template to construct novel linear oligopeptide foldamersand large-ring cyclic correlates with self-recognizing properties.
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