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| - Self-Association of Protected Newkome-Type Second-GenerationDendrimers at Nanomolar Level Concentrations in Aqueous Solution
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| - Protected Newkome-type second-generation dendrimers (based on Lin's amine) weresynthesized with a pyrene moiety attached to the core. The photophysical property in aqueous solutionof the protected dendrimers shows self-association behavior in water. Pyrene excimer emission at 475nm is observed in water even at very low concentrations of protected dendrimer (ca. 5 × 10-8 M). Thisemission band is absent in other solvents even up to a concentration of 10-5 M. The correspondingunprotected dendrimer does not show the pyrene excimer fluorescence. The amide of pyrene butyric acidwith tert-butylamine shows the formation of excimer, albeit with very low intensity. Quenching studieson the dendrimer with hydrophilic quencher iodide anion (I-) reveal that there is significant quenchingof fluorescence intensity in the case of N-tert-butyl-4-pyren-1-ylbutyramide as compared to that of thepyrene-attached second-generation protected dendrimer. This shows that the pyrene moiety in the caseof the protected dendrimer is significantly shielded from the surrounding.
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