| Abstract
| - The synthesis of chiral benzyl-α-d alcohols via the reduction of benzaldehyde-α-d derivatives has been investigated with a series of catalysts that were derived in situ from (1R,2S)-(+)-cis-1-amino-2-indanol and the organometallic dimers of p-CyRu, p-CyOs, Cp*Rh, or Cp*Ir. All four catalyst systems were found to produce chiral benzyl-α-d alcohols with high conversion (>98%). Modest to good enantioselectivities (up to 68% ee) were observed.
- The synthesis of chiral benzyl-α-d alcoholsvia the reduction of benzaldehyde-α-d derivatives hasbeen investigated with a series of catalysts that werederived in situ from (1R,2S)-(+)-cis-1-amino-2-indanoland the chloro-bridged dimers of p-cymeneRu, p-cymeneOs, Cp*Rh, or Cp*Ir. An unusual trend was observedin which substrates containing electron-withdrawingsubstituents led to greater enantioenrichment than thosewith electron-donating substituents. All four catalystsystems were found to produce benzyl-α-d alcohols withhigh conversion (>98%). Modest to good enantioselectivities (up to 68% ee) were observed.
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