| Abstract
| - The coupling of aryl boronic acids with aryl bromides and chlorides proceeds smoothly under mild conditions using the catalyst system comprised of Pd2(dba)3 and the chlorinated triphenylphosphine, P(C6H5)(2-C6H4Cl)2.
- The chlorinated triarylphosphine P(C6H5)(2-C6H4Cl)2 (1) has been used as a supportingligand in the Suzuki−Miyaura coupling of aryl boronic acids with aryl halides. Aryl bromideswithout ortho substituents were successfully coupled at room temperature, while reactionsinvolving sterically hindered aryl bromides required slight heating (70 °C). Electron-deficientaryl chlorides were also successfully coupled with heating (90 °C). Key reaction parameterssuch as order of addition, choice of mineral base, solvent volume, temperature, 1/Pd ratio,as well as electronic and steric variation of the aryl halide have been investigated and arereported.
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