| Abstract
| - A series ruthenium complexes with the chiral P−N ligand (1R,2R)-PPh2CHPhCHMeNH2derived from (1S,2R)-norephedrine are synthesized starting from the complexes RuHCl(PPh3)3 or RuHCl(P−P)(PPh3) (P−P= (R)-binap or (S)-binap). These are precatalysts for theefficient asymmetric hydrogenation of simple ketones. For the hydrogenation of acetophenoneto 1-phenylethanol, the enantioselectivity observed can be related to the structure of theprecatalysts determined by X-ray diffraction. This relationship breaks down for thehydrogenation of pinacolone.
- A series of ruthenium complexes with the chiral P−N ligand (1R,2R)-PPh2CHPhCHMeNH2 derived from (1S,2R)-norephedrine are synthesized starting from the complexes RuHCl(PPh3)3 or RuHCl(P−P)(PPh3), P−P = (R)-binap or (S)-binap. These are precatalysts for the efficient asymmetric hydrogenation of simple ketones. For the hydrogenation of acetophenone to 1-phenylethanol, the enantioselectivity observed can be related to the structure of the precatalysts determined by X-ray diffraction.
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