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À propos de : New Ortho-Directing Group for Lithiation: Use of aMethoxy−Imino Auxiliary for the Synthesis of ChiralOrtho-Substituted Acetyl- and Propionylferrocenes        

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  • New Ortho-Directing Group for Lithiation: Use of aMethoxy−Imino Auxiliary for the Synthesis of ChiralOrtho-Substituted Acetyl- and Propionylferrocenes
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  • Ortho lithiation of acetyl- and propionylferrocenes followed by addition of chlorosilane and diiodoethane was totally enantioselective using a chiral methoxy−imino auxiliary as an easily removable ortho-directing group. Enantiopure (R)-o-iodoacetylferrocene and (R)-o-iodopropionylferrocene were obtained, and the structure of iodoacetylferrocene was confirmed by X-ray crystallography.
  • Ortho lithiation of acetylferrocene and propionylferrocene followed by addition of chlorosilane anddiiodoethane was totally enantioselective when a chiral methoxy−imino auxiliary was used as an easilyremovable ortho-directing group. Enantiopure (R)-o-iodoacetylferrocene and (R)-o-iodopropionylferrocenewere obtained. The structure of (R)-o-iodoacetylferrocene was confirmed by X-ray crystallography.
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