| Abstract
| - Abstract. Objective To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months. Design Community based, randomised, double blind, placebo controlled trial. Setting Two rural districts of Tamil Nadu, southern India. Participants 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery. Main outcome measure Primary outcome measure was mortality at age 6 months. Results Infants in the vitamin A group had a 22% reduction in total mortality (95%confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months. Conclusion Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.
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