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Computer reminders to clinicians during routine activities produce only small improvements in adherence to processes of care: median improvement 4.2%, IQR 0.8-18.8%
Adding subcutaneous liraglutide to metformin reduces HbA1c more than adding oral sitagliptin in patients whose type 2 diabetes is poorly controlled with metformin alone
Aspirin prophylaxis (100 mg daily) does not improve cardiovascular outcomes compared to placebo in asymptomatic individuals with incidental low-ankle brachial index
Management of benign paroxysmal positional vertigo
An ‘e-Nudge’ electronic reminder system that highlights individuals at raised cardiovascular risk encourages GPs to improve the collection of patient cardiovascular risk factor data
Cognitive behavioural therapy shown to be an effective and low cost treatment for subacute and chronic low-back pain, improving pain and disability scores in a pragmatic RCT
Errors detected in 19% of paediatric medication preparations and administrations across five hospitals in London
Tamoxifen, raloxifene and tibolone decrease risk of invasive breast cancer in healthy women but increase risk of thromboembolism (tamoxifen, raloxifene), endometrial cancer (tamoxifen) or stroke (tibolone)
Being overweight in adults aged 70-75 is associated with a reduction in mortality risk compared with normal BMI
Evidence-based medicine: time for transition and translation (to practice)
Advanced practice nurses achieve results equal to or better than those of GPs in cardiovascular risk management in primary care
The 23-valent polysaccharide vaccine prevents pneumococcal pneumonia and reduces associated mortality in nursing home residents in Japan
Purpose and procedure
Angina relief with percutaneous coronary intervention versus medical therapy for chronic stable angina
Available evidence points to low effectiveness of influenza vaccines for older people
Dutasteride reduces incident prostate cancer in men after negative prostate biopsy
Meta-analysis of RCTs finds that increasing consumption of polyunsaturated fat as a replacement for saturated fat reduces the risk of coronary heart disease
Muscle cramps: quinine derivatives likely to be effective but not recommended for routine use due to toxicity; vitamin B complex, naftidrofuryl and calcium channel blockers possibly effective
No evidence for switching antidepressants in treatment-resistant depressed patients
BMI, waist circumference and fat composition are not correlated with mortality risk in an older Korean population, but higher lean mass and lean mass index are predictors of reduced mortality risk
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