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Paracetamol is more effective than placebo for migraine, and paracetamol 1000 mg plus metoclopramide 10 mg is similarly effective to oral sumatriptan 100 mg for migraine relief at 2 h
In preterm infants with recurrent apnoea, methylxanthine reduces the number of episodes and the use of mechanical ventilation in the short term; caffeine is also associated with improved longer term outcomes
Gestational weight loss in overweight and obese women is associated with an increased risk of small for gestational age infants
Varenicline increases smoking abstinence at 6 months to a year compared with placebo or bupropion; nausea is the most commonly reported adverse effect
Brief curriculum to teach residents study design and biostatistics
No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced
Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel
Catheter-based renal sympathetic denervation reduces systolic blood pressure by 32 mm Hg in people with treatment-resistant hypertension
Corticosteroid injection for lateral epicondylalgia is helpful in the short term, but harmful in the longer term; data for non-corticosteroid injections and other tendinopathies are limited
Valsartan is more effective than placebo in reducing the incidence of diabetes in people with impaired glucose tolerance and cardiovascular disease or risk factors but has no effect on cardiovascular outcomes
For sick-listed people with chronic low back pain, an integrated care programme costs society less and returns participants to work faster than usual management
Eplerenone reduces risk of cardiovascular death or hospitalisation in heart failure patients with reduced ejection fraction
A restrictive perioperative transfusion strategy does not increase all-cause mortality (30 days) or morbidity compared with a liberal approach in patients undergoing cardiac surgery
Evidence-based policymaking in global health - the payoffs and pitfalls
Treatment with the probiotic VSL#3 as an adjunctive therapy in relapsing mild-to-moderate ulcerative colitis significantly reduces ulcerative colitis disease activity
Multicentre trial in people with arthritis finds increased risk of clinically significant gastrointestinal events with diclofenac plus omeprazole compared with celecoxib
High-protein and low-glycaemic diets improve dietary compliance and maintenance of weight loss in overweight adults who have lost weight on a low-calorie diet
Six months following first unprovoked seizure, antiepileptic-treated adults have a recurrence risk in the following 12 months of significantly below the 20% threshold required to regain their driving license
Women with cytologically atypical glandular cells are at increased risk of developing gynaecological malignancy
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