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ebmed
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Evidence Based Medicine
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Evid Based Med
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http://hub.abes.fr/bmj/periodical/ebm/m/web
http://hub.abes.fr/bmj/periodical/ebm/m/print
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http://hub.abes.fr/bmj/periodical/ebm/1995/volume_1
http://hub.abes.fr/bmj/periodical/ebm/1996/volume_1
http://hub.abes.fr/bmj/periodical/ebm/1997/volume_2
http://hub.abes.fr/bmj/periodical/ebm/1998/volume_3
http://hub.abes.fr/bmj/periodical/ebm/1999/volume_4
http://hub.abes.fr/bmj/periodical/ebm/2007/volume_12
http://hub.abes.fr/bmj/periodical/ebm/2008/volume_13
http://hub.abes.fr/bmj/periodical/ebm/2009/volume_14
http://hub.abes.fr/bmj/periodical/ebm/2010/volume_15
http://hub.abes.fr/bmj/periodical/ebm/2011/volume_16
http://hub.abes.fr/bmj/periodical/ebm/2012/volume_17
http://hub.abes.fr/bmj/periodical/ebm/2013/volume_18
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is part of this journal
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Expectant management was as effective as D&C for spontaneous abortion
Pulmonary rehabilitation initially improved function and symptoms more than education in COPD
How to search for and find evidence about therapy
Intensified follow-up detected recurrent colorectal cancer earlier than did conventional follow-up but did not affect recurrence or survival
Multiple insulin injection therapy delayed microvascular complications in NIDDM
Purpose and Procedure (Abbreviated)
Pyronaridine was effective and well tolerated in African patients with acute, uncomplicated falcipamm malaria
Meta-analysis: Many factors affect mortality from community-acquired pneumonia
Open surgery led to fewer recurrent biliary symptoms than did endoscopic sphincterotomy in high-risk elderly patients
Purpose and Procedure (Abbreviated)
Meta-analysis: Shouldice technique is superior to the Bassini or McVay methods of hernia repair
Meta-analysis: Failure of oral rehydration therapy is infrequent in young, well-nourishedchildren with gastroenteritis
Atenolol reduced mortality and cardiovascular events after noncardiac surgery
Evidence-based pathology
Review: Low-dose diuretics, but not high-dose diuretics and β-blockers, reduce coronary heart disease and total mortality
Quality-of-life measures improved in a mild hypertension study
Review: Migraine frequency and severity guide symptomatic and prophylactic therapy
Review: Prophylactic antifungal treatment decreases systemic fungal infection but not mortality in cancer complicated by neutropenia
Correction
Indinavir plus zidovudine and lamivudine reduced HIV RNA levels in most HIV-infected persons with previous antiretroviral treatment
Review: Advice to stay active is effective for acute low-back pain but bed rest is not
Alendronate reduced new fractures in postmenopausal women who had low bone-mineral density and existing vertebral fractures
Review: Educational outreach visits combined with additional interventions reduce inappropriate prescribing by physicians
Review: Prophylactic antibiotics reduce mortality in critically ill adults
Review: Noninvasive tests are useful only for symptomatic deep venous thrombosis
Review: Antibiotics do not resolve acute cough
Evidence-based patient choice
4 anticonvulsant drug regimens had similar efficacies for generalized convulsive status epilepticus
Review: β-blockers benefit patients with chronic heart failure
Preclampsia and baseline proteinuria in women with chronic hypertension were associated with adverse neonatal outcomes
Bringing evidence to the point of care
Review: Amoxycillin and folate inhibitors are as effective as newer, more expensive antibiotics for acute sinusitis
Review: Computer-based clinical decision support systems can improve physician performance in some areas
An “evidence centre” in a general hospital: finding and evaluating the best available evidence for clinicians
Teaching patients to recognise early symptoms of relapse reduced manic relapses in bipolar disorder
A multicomponent programme increased physical function and decreased hospital days in older adults with chronic disease
Intermittent treatment with ranitidine or omeprazole for 1 year was effective for gastro-oesophageal reflux disease
Additional Articles Abstracted in ACP Journal Club
Continuous positive airways pressure was better than an oral appliance or conservative measures for mild to moderate obstructive sleep apnoea
In women with suspected TB, brief sputum-submission instruction improved sampling quality and TB detection
Review: available evidence does not support a benefit for thyroid hormone replacement in adults with subclinical hypothyroidism
Patients with lone atrial fibrillation had low risk of progression to permanent atrial fibrillation, death, congestive heart failure, and stroke
Treatment review by case conferences led to more medication changes than written feedback in older people on polypharmacy
Evidently…
Review: corticosteroids plus LABAs reduce exacerbations and mortality more than steroids alone in COPD
A patient-adjusted insulin algorithm was non-inferior to standard of care for glycaemic control in type 2 diabetes
Review: lower total cholesterol is associated with reduced risk of death from ischaemic heart disease but not stroke
Accuracy of ECG interpretation in primary care was limited for detecting atrial fibrillation
Other articles noted
Telling smokers their “lung age” promoted successful smoking cessation
Spectrum bias: why generalists and specialists do not connect
A simple paper-based patient decision aid
Low-carbohydrate and Mediterranean diets led to greater weight loss than a low-fat diet in moderately obese adults
Evidence in context: one person’s poison is another’s acceptable risk
To lower or not to lower? Making sense of the latest research on intensive glycaemic control and cardiovascular outcomes
Review: C-reactive protein has moderate diagnostic accuracy for serious bacterial infection in children with fever
Resource reviews
6-month treatment with a low-glycaemic diet was better than a high-fibre diet for glycaemic control in type 2 diabetes
Additional articles abstracted in ACP Journal Club
Concomitant use of proton pump inhibitors with clopidogrel may increase risk of readmission after discharge for acute MI
Resource reviews
Benefits of budesonide or nedocromil for mild to moderate asthma in children were not sustained after discontinuation
Neuraminidase inhibitors produce a small reduction in duration of seasonal influenza in children and reduce transmission in affected households, but effects on serious complications unclear
Compared with usual care, supervised exercise in primary care for people with patellofemoral syndrome does not significantly increase self-reported recovery but improves pain and function in the short term and pain in the long term
Quadrivalent HPV vaccine administered to women who became pregnant during trials did not appear to adversely affect pregnancy outcome; however, use during pregnancy is not recommended
Standard medical care does not offer sufficient relief of non-specific chest pain leading to additional diagnostic testing of no clinical benefit
Computer reminders to clinicians during routine activities produce only small improvements in adherence to processes of care: median improvement 4.2%, IQR 0.8-18.8%
Adding subcutaneous liraglutide to metformin reduces HbA1c more than adding oral sitagliptin in patients whose type 2 diabetes is poorly controlled with metformin alone
B-type natriuretic peptide-guided therapy for chronic heart failure reduces all-cause mortality compared with usual care but does not affect all-cause hospitalisation or survival free of hospitalisation
Higher BMI in pregnant women associated with a greater likelihood of pre-eclampsia, caesarian delivery and higher offspring birth weight and body fat
Low-dose and high-dose colchicine have comparable efficacy in the treatment of acute gout, but high dose carries significantly greater risk of adverse effects
Low-dose rosiglitazone plus metformin reduces risk of incident type 2 diabetes compared with placebo in people with impaired glucose tolerance
In diabetic nephropathy, high doses of vitamin B decrease glomerular filtration rate and increase risk of the composite outcome of a vascular event or all-cause mortality compared with placebo
Lowering systolic blood pressure below 130 mm Hg does not improve cardiovascular outcomes in hypertensive patients with diabetes and coronary artery disease
Does antiviral medication for treating herpes simplex during pregnancy increase the risk of birth defects in offspring?
Statins are not associated with a decrease in all cause mortality in a high-risk primary prevention setting
Consensus abstracts for evidence-based medicine
Percutaneous coronary intervention for acute coronary syndrome: no difference in 48-h bleeding rate or vascular access-site complications with low- or standard-dose unfractionated heparin in patients initially treated with fondaparinux
Sustained reduction in body mass index and other cardiovascular risk markers a year after a 12-month intensive family-based lifestyle intervention for obese children; but follow-up of participants low
Calcium supplements may increase the risk of cardiovascular events in postmenopausal women
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