| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| subtitle
| - Acteurs de la levée de pause transcriptionnelle, possibles cibles thérapeutiques
|
| License
| |
| Title
| |
| Date
| |
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - La physiologie d’une cellule est dictée par l’intégration des signaux qu’elle reçoit et la mise en place de réponses adaptées par le biais, entre autres, de programmes transcriptionnels adéquats. Pour assurer un contrôle optimal de ces réponses, des mécanismes de régulation ont été sélectionnés, dont un processus de pause transcriptionnelle et de levée de cette pause par P-TEFb ( positive transcription elongation factor) et Brd4 ( bromodomain-containing protein 4). Le dérèglement de ce processus peut conduire à l’apparition de pathologies. P-TEFb et Brd4 ont ainsi émergé au cours des dernières années comme des cibles thérapeutiques potentielles dans le cadre des cancers et du syndrome d‘immunodéficience acquise (sida) notamment.
- Most cell physiology events are dictated by the integration of perceived signals and the elaboration by cells of adapted answers via the execution of proper transcriptional programs. In order to ensure an optimal control of these answers, many regulation mechanisms have been selected throughout the evolution, thus allowing to fine-tune transcript expression. The transcriptional pause and its release by P-TEFb (Positive Transcription Elongation Factor) have been evidenced two decades ago. Since then, the importance of such mechanisms has been highlighted by the association between alterations of this machinery and the appearance of diseases. P-TEFb and Brd4 have thus recently emerged as potential therapeutical targets for cancers and AIDS notably. In this review, we present a brief case history and an up-to-date synthesis of models for transcriptional pause release. We later discuss on the pathophysiological processes associated with this mechanism and clinical trials targeting Brd4 and P-TEFb.
|
| article type
| |
| publisher identifier
| |
| Date Copyrighted
| |
| Rights
| - © 2018 médecine/sciences - Inserm
|
| Rights Holder
| - médecine/sciences - Inserm
|
| is part of this journal
| |
| is primary topic
of | |
