| Abstract
| - Angiotensin converting enzyme (ACE) inhibitors have additive effects with most other antihypertensive agents, but t h e mechanisms of these interactions vary. With diuretics the interaction with ACE inhibitors can be explained by their contrasting effects on the renin - angiotensin system, while with calcium antagonists it may be attributed to independent mechanisms of action. With β-blockers there is a variable additive effect, which has been proposed to be due to more complete blockade of the renin - angiotensin system than can be obtained with either type of agent alone. Am J Hypertens 1991;4:73S-78S
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