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| - Renal Effects of ANF (95-126), A New Atrial Peptide Analogue, in Dogs With Experimental Heart Failure
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| - Atrial natriuretic factor 95-126 [ANF (95-126)] is a novel 32 amino acid peptide which is thought to originate from the kidney. The systemic hemodynamic and renal effects of equimolar doses of intravenous synthetic ANF (95-126) and synthetic aANF (99-126) were examined in normal dogs (n = 6) and in dogs with an arteriovenous (AV) fistula and chronic compensated high-output heart failure (n = 5). ANF (95-126) and aANF (99-126) were infused at 5 and 10 pmol/kg/min for 75-min periods each. In the normal and AV fistula dogs the two peptides similarly decreased mean arterial pressures and right atrial pressures (P < .05). Creatinine clearance and urinary volume excretion increased (P < .05) in the normal dogs with both peptides, but only ANF (95-126) produced significant elevations (P < .05) of these two parameters in the AV fistula animals With the highest infusion dose, ANF (95-126) increased urinary sodium excretion to at least twice the levels observed with aANF (99-126) in both groups of dogs (P< .05). The decreases in plasma renin and aldosterone were comparable for the two peptides in both groups of animals. These results indicate that ANF (95-126) is more potent than αANF (99-126) for the promotion of a natriuresis, particularly in AV fistula dogs with compensated high-output heart failure, in which the sodium excretory actions of aANF (99-126) were attenuated markedly. Am J Hypertens 1991;4:508-515
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