| Abstract
| - Acrylonitrile, a carcinogen in rodents, is used in the large-scale production of acrylic polymers. 3-(Methylnitrosamino)propionitrile, a potent carcinogen in Fischer rats, is an Areca-derived nitrosamine which has been found in the saliva of betel quid chewers. Upon metabolic activation, both of these carcinogens can react with DNA to form 7-(2-cyanoethyl)guanine and O6-(2-cyanoethyl)guanine. The latter has never been described. We have therefore synthesized this derivative by reacting 2-(N-carbethoxy-N-nitrosamino)propionitrile with deoxyguanosine.
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