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| - Effect of digitalis on human ventricular refactoriness
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| - SUMMARY. In order to evaluate the effect of digitalis on the effective refractory period of the human ventricle, 14 patients were studied with atrial or ventricular pacing and with the introduction of ventricular extra-stimuli. The ventricular effective refractory period (VERP) was recorded before and after 1.0 to 1.25 mg ouabain given intravenously and the results compared with similar changes in the Q-T interval. During atrial pacing (eight patients) at rates of 70 to 110 beats per minute, ouabain reduced the mean ventricular effective refractory period from 290 ± 13 ms to 260 ± 16 ms (P<0.01) and the mean Q-T interval was reduced from 372± 18ms to 359± 19ms (P<0.01); the mean VERP/Q-T ratio was 0.79 ± 0.04 before ouabain and 0.73 ± 0.04 after ouabain (P<0.01). Utilising ventricular drive pacing (six patients) the mean ventricular effective refractory period was reduced from 245 ± 16 ms to 226 ± 13 ms (P<0.01) and the mean Q-T interval reduced from 382± 18ms to 360± 29ms (P<0.01). There was no significant change in the mean VERP/Q-T ratio (0.63 ± 0.04 before vs 0.63 ± 0.04 after ouabain). The results demonstrate that clinically effective doses of ouabain produce a significant reduction of the effective refractory period of the human ventricle. This change is accompanied by a reduction in the VERP/Q-T ratio during atrial pacing.
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