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| - Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries
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| - Objective: Radial arteries are increasingly used as grafts in coronary artery bypass surgery. The surgical preparation and intraoperative management of this conduit artery may affect its early and long-term patencies. We investigated the effects of the colloidal Biseko® and 5% albumin solutions as well as the crystalloid physiological saline (0.9% NaCl) and Bretschneider solutions on the contractile and relaxing capacities of isolated human radial artery grafts. Method: Radial artery segments were harvested using the technique with an ultrasonic scalpel, and 2.5-3 mm rings were obtained from the proximal part of the artery. Arterial rings were stored in Biseko® or 5% albumin solutions and in 0.9% NaCl or Bretschneider solutions for 45 min. Isometric tensions of radial arteries obtained from 26 patients were measured in isolated organ baths. Contractions were induced by 0.31 μmol L−1 5-hydroxytryptamine and 10 μmol L−1 noradrenaline. Endothelium-dependent relaxations were induced by 10 μmol L−1 acetylcholine and 1 μmol L−1 bradykinin as well as the endothelium-independent relaxations by 10 μmol L−1 glyceryl trinitrate and 100 μmol/l papaverine. Results: Contractions of radial arteries induced by 5-hydroxytryptamine were significantly lower following storage in Biseko® solution (12.6 ± 4.4 mN) than in 5% albumin (37.9 ± 13.0 mN, p = 0.03) or in 0.9% NaCl solution (35.9 ± 11.9 mN, p = 0.04). Noradrenaline-induced contractions of the arteries were also diminished in Biseko® solution compared to those stored in 5% albumin (32.9 ± 6.2 mN vs 49.2 ± 6.4 mN, p = 0.01). No significant differences in relaxations were obtained between the two crystalloid and the two colloidal solutions using endothelium-dependent and independent vasorelaxants. Conclusion: Our results suggest that storage of radial artery in Biseko® colloidal solution before coronary artery bypass grafting decreases the sensitivity of the graft to vasoconstriction, thereby decreasing the risk of intra/perioperative graft failure.
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