| Abstract
| - Background. We report data showing the incidence of new coronary events in diabetics with prior myocardial infarction (MI), nondiabetics with prior MI, diabetes with no coronary artery disease (CAD), and nondiabetics with no CAD who were treated with and without statins. Methods. We investigated—in an observational prospective study of 274 diabetics and 386 nondiabetics with peripheral arterial disease, mean age \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(80\ {\pm}\ 9\) end{document} years, and a serum low-density lipoprotein cholesterol level of ≥125 mg/dl—the incidence of new coronary events in diabetics with prior MI, nondiabetics with prior MI, diabetics with no CAD, and nondiabetics with no CAD who were treated with and without statins. Follow-up was \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(39\ {\pm}\ 23\) end{document} months. Results. In patients treated with statins, the incidence of new coronary events was 73% in diabetics with prior MI (group 1), 37% in nondiabetics with prior MI (group 2), 57% in diabetics with no CAD (group 3), and 27% in nondiabetics with no CAD (group 4). In patients treated with no lipid-lowering drug, the incidence of new coronary events was 91% in diabetics with prior MI (group 5), 72% in nondiabetics with prior MI (group 6), 86% in diabetics with no CAD (group 7), and 52% in nondiabetics with no CAD (group 8). Significant p values were \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {<}.0001\) end{document} for group 1 versus 2, group 7 versus 8, and group 2 versus 6; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.0006\) end{document} for group 3 versus 4; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.0007\) end{document} for group 3 versus 7; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.001\) end{document} for group 5 versus 6; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.002\) end{document} for group 4 versus 8; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.003\) end{document} for group 1 versus 5; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.015\) end{document} for group 2 versus 3; and \batchmode \documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathit{p}\ {=}.047\) end{document} for group 6 versus 7. Conclusions. In patients treated with and without statins, diabetics with no CAD had a higher incidence of new coronary events than did nondiabetics with prior MI.
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