Documentation scienceplus.abes.fr version Bêta

À propos de : Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting
has manifestation of work
related by
Author
Abstract
  • Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen ins typically mucb less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLA mediated restricution of the Immune response. In this study we have investigated the role of HLA and non-HLA genes in the antibody response to two merozoite surface antigens (MSP1 and MSP2) and a sexual stage antigen (Pfs260/230) opf P{lasmodium falcpartum, and conclude that host genotype is not a major determinant of responsiveness. Although antibody levels vary in accordance with seasonal variations in malaria transmission in semi-immune children, antibiody levels remain stable in clncall immine adults.
article type
publisher identifier
  • 8.6.905
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata