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| - CD11b Limits Bacterial Outgrowth and Dissemination during Murine Pneumococcal Pneumonia
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| - Expression of CD11b is enhanced on neutrophils recruited to the lungs during bacterial pneumonia. To determine the role that CD11b plays in pneumonia, CD11b gene-deficient (CD11b-/-) mice and normal wildtype (wt) mice were intranasally infected with Streptococcus pneumoniae. CD11b-/- mice had an enhanced outgrowth of pneumococci in the lungs and an increased dissemination of the infection, which could be reproduced by treatment of wt mice with an anti-CD11b antibody. This reduced resistance was associated with higher neutrophil counts in bronchoalveolar lavage fluid and lung tissue and an exaggerated lung in- flammatory response. CD11b is important for an effective defense against S. pneumoniae pneumonia but not for recruitment of neutrophils.
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