| Abstract
| - Anti-CEA serum was prepared by immunizing rabbits with a crude CEA fraction obtained from perchloric acid soluble extracts of adenocarcinoma of the stomach. After absorption, the antiserum proved to be monospecific for CEA. With Mancini's technique, CEA concentrations in perchloric acid extracts of carcinomatous and noncarcinomatous tissues were quantitatively determined and expressed in terms of unit/ml, equivalent to mg/ml protein concentration of standard CEA solution. Finally, ratios of CEA units per mg protein (CEA/P) of tissue extract were calculated. The CEA/P ratios tended to be higher in extracts from colonic, rectal and pancreatic carcinomas than in those from gastric carcinoma, whereas they were lower in those from primary hepatoma and lung cancer. In the same patients with cancer, the ratios for carcinoma tissues were remarkably higher than those for the noncarcinomatous counterparts. However, the ratios were not related to the histological types of cancers. Relatively high ratios were also observed in diseased intestinal mucosa of colonic polyposis and Crohn's disease, as well as in parts of gastric mucosa with a marked intestinal metaplasia obtained from a cancerous stomach. More studies will be required to evaluate the significance of occurrence in precancerous changes in tissues.
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