| Abstract
| - The effects of dimethylsulfoxide on the activities of purified human placenta) DNA polymerase α and DNA polymerase δ were examined. DNA polymerase α was inhibited by dimethylsulfoxide, whereas DNA polymerase δ was significantly activated, by as much as 6-fold. Kinetic data show that the effect of dimethylsulfoxide on DNA polymerase δ activity was due to a reduction in the apparent Km for its substrate, dTTP. This novel finding of the differential effects of dimethylsulfoxide on the activities of polymerases α and δ may be useful in their identification and differential assay.
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