About: Stabilization of T4 polynucleotide kinase by macromolecular crowding

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Attributs	Valeurs
type	work Article
Is Part Of	http://hub.abes.fr/oup/periodical/nar/1986/volume_14/issue_4/w
Subject	Articles
Title	Stabilization of T4 polynucleotide kinase by macromolecular crowding
has manifestation of work	http://hub.abes.fr/oup/periodical/nar/1986/volume_14/issue_4/101093nar1441863/m/print http://hub.abes.fr/oup/periodical/nar/1986/volume_14/issue_4/101093nar1441863/m/web
related by	http://hub.abes.fr/oup/periodical/nar/1986/volume_14/issue_4/101093nar1441863/authorship/2 http://hub.abes.fr/oup/periodical/nar/1986/volume_14/issue_4/101093nar1441863/authorship/1
Author	Harrison Barbara Zimmerman Steven B.
Abstract	T4 polynucleotide kinase rapidly loses activity during Its reaction on duplex DNA termini. Addition of high concentrations of nonspecific polymers reverses or prevents this lnactivation. In contrast, additions of related materials of lower molecular weight are relatively Ineffective In stabilizing the kinase. Such a pattern suggests that the stabilizing effects of polymers on kinase activity are due to macromolecular crowding. An effect of crowding on the known tendency of the kinase to undergo oligomerlzation reactions is consistent with our observations.
article type	research-article
publisher identifier	14.4.1863
is part of this journal	Nucleic Acids Research

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