| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| Title
| - Serum β2 Microglobulin and Extracellular Fluid Volume During Haemodialysis
|
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - Conflicting results have been published concerning serum β2 microglobulin (β2-M) kinetics during dialysis with a cuprophane membrane which is not permeable for the protein. We have investigated the hypothesis that the apparent increase of free serum β2-M could result from extracellular fluid volume (ECV) contraction. Using inulin, ECV was measured before and 1 h after a dialysis session with a sodium dialysate concentration of 145 mmol/l. Dialysis was performed either with a cuprophane or a high-flux membrane. Transcellular water shift and changes in β2-M concentration were calculated from total body water changes (ultrafiltration) and ECV. ECV decreased from a predialysis value of 16.6±3.51 (mean±SD) (24.9% bodyweight) to a postdialysis value of 11.9±2.11 (19.8% bodyweight). Ultrafiltration was only 3.1±1.01, indicating concomitant water shift from ECV to intracellular fluid space. A significant decrease in corrected β2-M concentration was found for high-flux membranes. However, postdialysis β2-M did not change significantly after dialysis with cellulosic membranes. In conclusion, the apparent increase of serum β2-M concentration measured during dialysis with cellulosic membranes may be explained by ECV contraction. These results have to be taken into account for any pathogenic mechanism of the β2-M-associated amyloidosis occurring in long-term haemodialysed patients.
|
| article type
| |
| publisher identifier
| |
| is part of this journal
| |
