| Abstract
| - A Three-Generation Rat Reproductive Toxicity Study of Vinylidene Chloride in the Drinking Water. Nitschke, K.D., Smith, F.A., Quast, J.F., Norris, J.M. and Schwetz, B.A. (1983). Fundam. Appl. Toxicol. 3:75-79. A reproduction study was conducted with Sprague-Dawley rats to evaluate the effects of parental exposure through three generations to drinking water containing 0, 50, 100 or 200 ppm vinylidene chloride (VDC) on reproduction and the development of the resultant offspring. A low fertility rate was observed in three of the four groups including controls, for the fo generation rats. Remating the f0 adults to produce the f1b litters resulted in a lower fertility of dams ingesting 200 ppm VDC than of dams ingesting 0, 50 or 100 ppm. However, the fertility index of the f0 dams ingesting 200 ppm VDC in the drinking water was higher for the f1b litters than for the f1a litters. No overall decrease in fertility was observed in subsequent matings to produce the f2, f3a, f3b or f3c litters. Although neonatal survival was decreased from concurrent control values in the f2 and f3a litters of dams ingesting VDC in the drinking water, the survival indices of the f2 litters were within the range of control values for this strain of rat in this laboratory. The apparent effect seen in the f3. litters was not repeated in subsequent matings of the same adults to produce either the f3b or the f3c litters. Consequently, the decreased survival observed in the f3a was interpreted as being due to chance. Histopathologic examination of tissues of rats (f1 and f2 adults) exposed to vinylidene chloride in the drinking water in utero, during lactation, and post weaning revealed slight hepatocellular fatty change and an accentuated hepatic lobular pattern of a reversible nature in the adult rats. In conclusion, ingestion of drinking water containing vinylidene chloride at concentrations which caused mild, dose-related changes in the liver, did not affect the reproductive capacity of rats through three generations which produced six sets of litters.
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