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À propos de : Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine® administration        

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  • Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine® administration
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  • Abstract. Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine were measured using a high performance liquid chromatographic method. The detection limit in plasma and urine was 5 ng/ml for chlorproguanil and 10 ng/ml for chlorcycloguanil. The elimination half-life of chlorproguanil (Lapudrine®) in 2 healthy volunteers, after a single oral dose of the drug, was 14·7 and 16·1 h. No chlorcycloguanil could be detected in plasma over 32 h after dosing.
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