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À propos de : Determination of minimum effective concentration of praziquantel in in vitro cultures of protoscoleces of Echinococcus granulosus        

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  • Determination of minimum effective concentration of praziquantel in in vitro cultures of protoscoleces of Echinococcus granulosus
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  • Abstract. The minimum effective concentration of praziquantel against protoscoleces of Echinococcus granulosus (ovine strain) was determined in vitro; 20 μg/litre gave statistically significant results. No difference was seen between the sensitivity of ovine and equine protoscoleces at 50 μg/litre. Morphological observations on treated protoscoleces and passage into gerbils both suggested that the eosin-exclusion technique overestimates viability. Electron microscopy of treated protoscoleces showed severe, disruptive tegumentary damage. Praziquantel is thus an extremely active protoscolicidal agent that may have an important peri-operative role in preventing recurrence.
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