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Risks of Nanotechnology Remain Uncertain
Will the Dragon Stay Green? China after the Beijing Olympics
Screening Out Legal Invaders
Allosteric Behavior in Cytochrome P450-Dependent inVitro Drug−Drug Interactions: A Prospective Based onConformational Dynamics
Engineering Cytochrome P450 Enzymes
A Tale of Two Fish
Leptin, a Pleiotropic Hormone: Physiology, Pharmacology, and Strategies forDiscovery of Leptin Modulators
Emerging Molecular Approaches to Pain Therapy
Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery
Property-Based Design: Optimization of Drug Absorption andPharmacokinetics
Purine and Pyrimidine (P2) Receptors as Drug Targets
Human β-Secretase (BACE) and BACE Inhibitors
Multidrug Resistance Reversal Agents
The Endocannabinoid System: Drug Targets, Lead Compounds, and PotentialTherapeutic Applications
Cytochrome P450 in Silico: An Integrative Modeling Approach
Approaches to Antiobesity Therapy. An Introduction
Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity
Prediction of Protein−Ligand Interactions. Docking and Scoring: Successes and Gaps
Current and Emerging Targets To Treat Neuropathic Pain
Combinatorial Biosynthesis of Natural Products
Asymmetric Allylic Alkylation, an Enabling Methodology
Joys of Molecules. 1. Campaigns in Total Synthesis
Perspective on Dirhodium Carboxamidates as Catalysts
Development of Cancer Chemopreventive Agents:Oltipraz as a Paradigm
Metabolites and Safety: What Are the Concerns, and How ShouldWe Address Them?
Allergic Contact Dermatitis--Formation, Structural Requirements, and Reactivity of Skin Sensitizers
Agricultural Chemistry and Bioenergy
Modulators of Leukotriene Biosynthesis and Receptor Activation
Serine−Threonine Protein Phosphatase Inhibitors: Development of PotentialTherapeutic Strategies
Antibiotic Glycosyltransferases: Antibiotic Maturation and Prospects forReprogramming
Ernest Guenther Award in Chemistry of Natural Products. Amphibian Skin: ARemarkable Source of Biologically Active Arthropod Alkaloids
Lessons Learned from Marketed and Investigational Prodrugs
Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups
N-Methyl-d-Aspartate Antagonists and Neuropathic Pain: The Search for Relief
Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery
The Protein Data Bank (PDB), Its Related Services and Software Tools as Key Components for In Silico Guided Drug Discovery
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor
Some Got Away, but Others Didn't...
Personal Reflections on Receiving the Roger Adams Award inOrganic Chemistry
Rings, Radicals, and Regeneration:The Early Years of a Bioorganic Laboratory
The Art of Building Small: From Molecular Switches to MolecularMotors
Lessons from Nature: Biomimetic Organocatalytic Carbon−Carbon Bond Formations
Internationally Recognized Ecology Lab Shrinks Its Operations
Future of ToxicologyMechanisms of Toxicity and Drug Safety: Where Do We Go from Here?
Chemical Toxicology of Reactive Intermediates Formed by the Glutathione-Dependent Bioactivation of Halogen-Containing Compounds
Small Molecule Conformational Preferences Derived from Crystal Structure Data. AMedicinal Chemistry Focused Analysis
Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation inAntihypertensive Therapy
2003 Claude S. Hudson Award Address in Carbohydrate Chemistry.Heparin: Structure and Activity
Nicotinic Acid Receptor Agonists
Emerging Opportunities for Antipsychotic Drug Discovery in the Postgenomic Era
Chiral Oxazolines and Their Legacy in AsymmetricCarbon−Carbon Bond-Forming Reactions
Crossing Conventional Boundaries in Half a Century of Research
Novel Organic Materials through Control of MultichromophoreInteractions
Analytical Advantages of Multivariate Data Processing. One, Two, Three, Infinity?
Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailabilityin the Smoker
PERSPECTIVE: Biofueling Water Problems
Peptidomimetic Growth Hormone Secretagogues. Design Considerations andTherapeutic Potential
Ligands for Glutamate Receptors: Design and Therapeutic Prospects
Current Clinical and Preclinical Photosensitizers for Use in PhotodynamicTherapy
Selective Optimization of Side Activities: Another Way for Drug Discovery
The Preorganization Step in Organic Reaction Mechanisms.Charge-Transfer Complexes as Precursors to ElectrophilicAromatic Substitutions
Electrophilic Intermediates and Their Reactions in Superacids
Small Molecule Natural Products in the Discovery of TherapeuticAgents: The Synthesis Connection
Paclitaxel from Primary Taxanes: A Perspective on CreativeInvention in Organozirconium Chemistry
Atrazine Effects in Xenopus Aren't Reproducible
Shape Selectivity for Constrained Solutes inReversed-Phase Liquid Chromatography
Future of ToxicologyLow-Dose Toxicology and Risk−BenefitAnalysis
Future of ToxicologyLipidomics, an Important Emerging Area forToxicologists: Focus on Lipid Oxidation Products
Bulky DNA Lesions Induced by Reactive Oxygen Species
Grapes and Human Health: A Perspective
G-Protein Coupled Receptors: Models, Mutagenesis, and Drug Design
Therapeutic Opportunities for Muscarinic Receptors in the Central NervousSystem
Higher-End Serotonin Receptors: 5-HT5, 5-HT6, and 5-HT7
Dopamine D3 Receptor Partial Agonists and Antagonists as Potential DrugAbuse Therapeutic Agents
From Diatomics to Drugs and Distributions
Obesity: The Disease
Ca2+ Channel α2-δ Ligands for the Treatment of Neuropathic Pain
Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists
Small Molecule Modulators of Toll-like Receptors
Histone Deacetylase Inhibitors: From Bench to Clinic
Metal−Ligand Bifunctional Catalysis: A Nonclassical Mechanismfor Asymmetric Hydrogen Transfer between Alcohols andCarbonyl Compounds
From the Design of a Chiral Lewis Acid Catalyst toMetal-Catalyzed Coupling Reactions
Impossible Dreams
Adventures in Sulfur−Nitrogen Chemistry
A Case for the Genotoxicity of Ochratoxin A byBioactivation and Covalent DNA Adduction
The Future of ToxicologyDoes It Matter How Cells Die?
15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses
hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias
Mechanisms of Protein Damage Induced by Cysteine Thiyl Radical Formation
DDT's Resurrection
Scaling Peaks: The Life and Science of Walter Giger
Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation
Peptide Science: Exploring the Use of Chemical Principles andInterdisciplinary Collaboration for Understanding Life Processes
Immobilized Artificial Membrane HPLC in Drug Research
Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes
5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists as Potential Antiobesity Agents
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