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type	Concept
rdfs:label	Basic and translational research
skos:inScheme	http://hub.abes.fr/referentiel/bmjarticlecategories
is Subject of	Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction Genetic variation in the nuclear factor κB pathway in relation to susceptibility to rheumatoid arthritis Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade Serum levels of tumour necrosis factor family members a proliferation-inducing ligand (APRIL) and B lymphocyte stimulator (BLyS) are inversely correlated in systemic lupus erythematosus Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis Antifibroblast antibodies from systemic sclerosis patients bind to α-enolase and are associated with interstitial lung disease Increased expression of the endothelin system in arterial lesions from patients with giant-cell arteritis: association between elevated plasma endothelin levels and the development of ischaemic events Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus Altered dynamics of transforming growth factor β (TGF-β) receptors in scleroderma fibroblasts Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment Monocyte migration to the synovium in rheumatoid arthritis patients treated with adalimumab Expression and function of toll-like receptors in peripheral blood mononuclear cells of patients with polymyalgia rheumatica and giant cell arteritis TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis Comparison of rheumatoid articular adipose and synovial tissue reactivity to proinflammatory stimuli: contribution to adipocytokine network The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4 A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells Bortezomib attenuates murine collagen-induced arthritis Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1β by mononuclear cells through a caspase 1-mediated process Endothelin and sex hormones modulate the fibronectin synthesis by cultured human skin scleroderma fibroblasts Interleukin-1 is essential for systemic inflammatory bone loss Persistent activation of dermal fibroblasts from patients with gadolinium-associated nephrogenic systemic fibrosis Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G IL-33 is overexpressed in the inflamed arteries of patients with giant cell arteritis IL-17-producing CD4−CD8− T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis Evidence for a distinctive pattern of bone formation in enthesophytes Urinary T cells in active lupus nephritis show an effector memory phenotype Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis Clinical features and functional significance of the P369S/R408Q variant in pyrin, the familial Mediterranean fever protein ANCA-associated vasculitis is linked to carriage of the Z allele of α1 antitrypsin and its polymers Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis Mutations of the cystic fibrosis gene in patients with bronchiectasis associated with rheumatoid arthritis High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3 Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY Differential synovial Th1 cell reactivity towards Escherichia coli antigens in patients with ankylosing spondylitis and rheumatoid arthritis Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS) Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis Regulatory B cells in ANCA-associated vasculitis Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2 Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor α therapy in rheumatoid arthritis Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance Identification of dairy fractions with anti-inflammatory properties in models of acute gout Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis Role of IL-17 in the Th1 systemic defects in rheumatoid arthritis through selective IL-12Rβ2 inhibition IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis Tolerogenic dendritic cells inhibit antiphospholipid syndrome derived effector/memory CD4+ T cell response to β2GPI CCAAT/enhancer binding protein β regulates expression of matrix metalloproteinase-3 in arthritis Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1 Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model

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