About: Therapeutics

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type	Concept
rdfs:label	Therapeutics THERAPEUTICS
skos:inScheme	http://hub.abes.fr/referentiel/bmjarticlecategories
is Subject of	Expectant management was as effective as D&C for spontaneous abortion Pulmonary rehabilitation initially improved function and symptoms more than education in COPD Intensified follow-up detected recurrent colorectal cancer earlier than did conventional follow-up but did not affect recurrence or survival Multiple insulin injection therapy delayed microvascular complications in NIDDM Pyronaridine was effective and well tolerated in African patients with acute, uncomplicated falcipamm malaria Open surgery led to fewer recurrent biliary symptoms than did endoscopic sphincterotomy in high-risk elderly patients Meta-analysis: Shouldice technique is superior to the Bassini or McVay methods of hernia repair Meta-analysis: Failure of oral rehydration therapy is infrequent in young, well-nourishedchildren with gastroenteritis Atenolol reduced mortality and cardiovascular events after noncardiac surgery Review: Low-dose diuretics, but not high-dose diuretics and β-blockers, reduce coronary heart disease and total mortality Quality-of-life measures improved in a mild hypertension study Review: Migraine frequency and severity guide symptomatic and prophylactic therapy Review: Prophylactic antifungal treatment decreases systemic fungal infection but not mortality in cancer complicated by neutropenia Indinavir plus zidovudine and lamivudine reduced HIV RNA levels in most HIV-infected persons with previous antiretroviral treatment Review: Advice to stay active is effective for acute low-back pain but bed rest is not Alendronate reduced new fractures in postmenopausal women who had low bone-mineral density and existing vertebral fractures Review: Prophylactic antibiotics reduce mortality in critically ill adults Review: Antibiotics do not resolve acute cough 4 anticonvulsant drug regimens had similar efficacies for generalized convulsive status epilepticus Review: β-blockers benefit patients with chronic heart failure Review: Amoxycillin and folate inhibitors are as effective as newer, more expensive antibiotics for acute sinusitis Teaching patients to recognise early symptoms of relapse reduced manic relapses in bipolar disorder A multicomponent programme increased physical function and decreased hospital days in older adults with chronic disease Intermittent treatment with ranitidine or omeprazole for 1 year was effective for gastro-oesophageal reflux disease Continuous positive airways pressure was better than an oral appliance or conservative measures for mild to moderate obstructive sleep apnoea In women with suspected TB, brief sputum-submission instruction improved sampling quality and TB detection Review: available evidence does not support a benefit for thyroid hormone replacement in adults with subclinical hypothyroidism Treatment review by case conferences led to more medication changes than written feedback in older people on polypharmacy Review: corticosteroids plus LABAs reduce exacerbations and mortality more than steroids alone in COPD A patient-adjusted insulin algorithm was non-inferior to standard of care for glycaemic control in type 2 diabetes Telling smokers their “lung age” promoted successful smoking cessation Low-carbohydrate and Mediterranean diets led to greater weight loss than a low-fat diet in moderately obese adults 6-month treatment with a low-glycaemic diet was better than a high-fibre diet for glycaemic control in type 2 diabetes Benefits of budesonide or nedocromil for mild to moderate asthma in children were not sustained after discontinuation Neuraminidase inhibitors produce a small reduction in duration of seasonal influenza in children and reduce transmission in affected households, but effects on serious complications unclear Compared with usual care, supervised exercise in primary care for people with patellofemoral syndrome does not significantly increase self-reported recovery but improves pain and function in the short term and pain in the long term Quadrivalent HPV vaccine administered to women who became pregnant during trials did not appear to adversely affect pregnancy outcome; however, use during pregnancy is not recommended Computer reminders to clinicians during routine activities produce only small improvements in adherence to processes of care: median improvement 4.2%, IQR 0.8-18.8% Adding subcutaneous liraglutide to metformin reduces HbA1c more than adding oral sitagliptin in patients whose type 2 diabetes is poorly controlled with metformin alone B-type natriuretic peptide-guided therapy for chronic heart failure reduces all-cause mortality compared with usual care but does not affect all-cause hospitalisation or survival free of hospitalisation Low-dose and high-dose colchicine have comparable efficacy in the treatment of acute gout, but high dose carries significantly greater risk of adverse effects Low-dose rosiglitazone plus metformin reduces risk of incident type 2 diabetes compared with placebo in people with impaired glucose tolerance In diabetic nephropathy, high doses of vitamin B decrease glomerular filtration rate and increase risk of the composite outcome of a vascular event or all-cause mortality compared with placebo Statins are not associated with a decrease in all cause mortality in a high-risk primary prevention setting Percutaneous coronary intervention for acute coronary syndrome: no difference in 48-h bleeding rate or vascular access-site complications with low- or standard-dose unfractionated heparin in patients initially treated with fondaparinux Sustained reduction in body mass index and other cardiovascular risk markers a year after a 12-month intensive family-based lifestyle intervention for obese children; but follow-up of participants low Calcium supplements may increase the risk of cardiovascular events in postmenopausal women The allergy protective effects of fish oil: A matter of timing? In premenopausal women with recurrent UTI, antibiotics were more effective than capsules of cranberry extract for the prevention of UTI, but resistance was higher in the antibiotic group Evening dosing of antihypertensive medications results in better blood pressure control and decreases cardiovascular morbidity and mortality in patients with Type 2 diabetes Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone Review: β-agonists plus ipratropium bromide improve airflow obstruction in adults with acute asthma Glucocorticoids reduced short-term treatment failure in exacerbations of chronic obstructive pulmonary disease Laparoscopic hernia repair reduced recovery time and days of postoperative analgesia use better than Shouldice repair Raloxifene reduced vertebral fractures in postmenopausal women Angioplasty was no better than medication for reducing blood pressure or slowing disease progression in renal artery stenosis Review: anticonvulsant drugs relieve chronic but not acute pain Routine primary immunisation using a longer needle resulted in fewer local reactions in infants Review: the levonorgestrel releasing intrauterine system prevents more pregnancies than intrauterine devices (IUDs) ≤250 mm2 but not IUDs >250 mm2 Antibiotics did not prevent adverse outcomes in women in preterm labour with intact fetal membranes Patient education to encourage graded exercise improved physical functioning in chronic fatigue syndrome Review: intrinsic and environmental risk factor modification reduces falls in elderly people Low dose budesonide improved asthma control in mild asthma; adding formoterol improved control in corticosteroid treated patients A multidisciplinary community based rehabilitation programme improved social functioning in severe traumatic brain injury Oestrogen plus progestogen increased coronary heart disease and breast cancer events in postmenopausal women Review: advice on low fat diets is not better than other weight-reducing diets for sustaining weight loss in obesity Long term oestrogen plus progestin increased venous thromboembolism and biliary tract surgery in postmenopausal women Self management with the Angina Plan reduced anxiety, depression, angina attacks, and use of medication Noninvasive Helicobacter pylori testing was as effective as endoscopy for managing dyspepsia Treatment of scalp lacerations with a hair apposition technique reduced scarring, pain, and procedure duration compared with suturing Review: regular medical review is equivalent to written self management plans for optimising asthma control in adults Educational interventions improved some quality of life outcomes in prostate cancer Review: rotavirus vaccines moderately reduce rotavirus diarrhoea in children Below knee elastic compression stockings reduced development of the post-thrombotic syndrome in proximal deep venous thrombosis Review: statins reduce stroke but not stroke mortality Diuretic based therapy reduced CV mortality in older patients with isolated systolic hypertension and diabetes Cognitive behaviour therapy reduced relapses in recurrent major depressive disorder Review: a peridischarge multidisciplinary treatment programme reduces readmissions in heart failure Review: bright light therapy and dawn simulation reduce symptom severity in seasonal affective disorder The Bug Buster kit was better than single dose pediculicides for head lice Review: long term use of hormone therapy by postmenopausal women does not prevent chronic diseases Identifying hospice-appropriate nursing home residents for physicians increased hospice referrals and enrolment Review: ACE inhibitors delay microalbuminuria in diabetes without nephropathy and reduce mortality in diabetic nephropathy Raloxifene produced both harms and benefits in postmenopausal women, with no reduction in cardiovascular disease risk Corticosteroid injections or physiotherapy were not more effective than wait and see for tennis elbow at 1 year Physical counterpressure manoeuvres reduced vasovagal syncope Continuing alendronate for an additional 5 years maintained bone mineral density in postmenopausal women Etomidate had shorter induction and recovery times than midazolam for fracture reduction Review: bona fide psychotherapies are similar in effectiveness Donepezil improved cognitive and global function in mild to moderate Alzheimer's disease Personal therapy reduced adverse outcomes in patients with schizophrenia living with family but increased psychotic relapse rates in those living independently; personal therapy improved social adjustment but increased anxiety Review: oestrogen therapy after menopause may improve cognitive performance and may reduce the risk of developing dementia Review: self help interventions alone minimally increase smoking cessation Cognitive behavioural therapy was effective for adolescent depression after controlling for adverse predictors of outcome Bupropion alone or with a nicotine patch increased smoking cessation rates Traditional child psychotherapy did not reduce psychopathology compared with academic tutoring

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