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Should we prescribe diuretics for patients with prediabetes and hypertension?
Should selective digestive decontamination be used in critically ill patients?
Should statins be prescribed for primary prevention of cardiovascular disease in patients with chronic kidney disease?
Managing the anticoagulated patient with atrial fibrillation at high risk of stroke who needs coronary intervention
Should treatment for heart failure with preserved ejection fraction differ from that for heart failure with reduced ejection fraction?
Does mindfulness based cognitive therapy prevent relapse of depression?
What factors influence prognosis in children with acute cough and respiratory tract infection in primary care?
Do uterine fibroids cause infertility and should they be removed to increase fertility?
Should we use bath emollients for atopic eczema?
Do antidepressants improve negative symptoms in schizophrenia?
How beneficial is surgery for cervical radiculopathy and myelopathy?
Does home oxygen benefit people with chronic heart failure?
Should antihistamines be used to treat anaphylaxis?
Does first trimester progesterone prophylaxis increase the live birth rate in women with unexplained recurrent miscarriages?
Non-alcoholic fatty liver disease in children
Should women with HIV, or at high risk of contracting HIV, use progestogen-containing contraception?
How effective are some common treatments for traumatic brain injury?
Does routine oxygen supplementation in patients with acute stroke improve outcome?
Should we use individual cognitive stimulation therapy to improve cognitive function in people with dementia?
How effective are non-drug, non-surgical treatments for primary dysmenorrhoea?
Should more patients with acute ischaemic stroke receive thrombolytic treatment?
Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?
Should we treat uncomplicated symptomatic diverticular disease with fibre?
Should inpatient hyperglycaemia be treated?
What is the best way to deliver subcutaneous insulin to infants, children, and young people with type 1 diabetes mellitus?
How best to diagnose urinary tract infection in preschool children in primary care?
How big a problem is non-alcoholic fatty liver disease?
What is the optimal management of partial epilepsy uncontrolled by a first choice anticonvulsant?
Should we screen and decolonise contacts of patients with Panton Valentine leukocidin associated Staphylococcus aureus infection?
Does gluten sensitivity in the absence of coeliac disease exist?
Is closure of patent foramen ovale to prevent ischaemic stroke ever justified?
How can we best prevent new foot ulcers in people with diabetes?
Does avoidance of peanuts in early life reduce the risk of peanut allergy?
Research to decrease areas of clinical uncertainty
What is the most effective way to maintain weight loss in adults?
What is the most effective treatment of interstitial cystitis?
Should we treat subclinical hypothyroidism?
How does the level of BCG vaccine protection against tuberculosis fall over time?
What is the most effective management of neurogenic bladder dysfunction?
How should we manage fear of falling in older adults living in the community?
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