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type	Concept
rdfs:label	BIOTRANSFORMATION AND TOXICOKINETICS Biotransformation and Toxicokinetics
skos:inScheme	http://hub.abes.fr/referentiel/ouparticlecategories
is Subject of	The Cruciferous Nitrile, Crambene, Induces Rat Hepatic and Pancreatic Glutathione S-Transferases Metabolism and Distribution of [2,3-14C]Acrolein in Sprague-Dawley Rats Analysis of Respiratory Exchange of Methanol in the Lung of the Monkey Using a Physiological Model Sensitivity Analysis of a Physiological Model for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Assessing the Impact of Specific Model Parameters on Sequestration in Liver and Fat in the Rat Toward a Biologically Based Dose-Response Model for Developmental Toxicity of 5-Fluorouracil in the Rat: A Mathematical Construct Influence of Dietary Manganese on the Pharmacokinetics of Inhaled Manganese Sulfate in Male CD Rats In Vitro Bioavailability of Heavy Metals in Pressure-Treated Wood Dust Persistence and Reversibility of the Elevation in Free Sphingoid Bases Induced by Fumonisin Inhibition of Ceramide Synthase Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise In Vitro Rat Hepatic and Intestinal Metabolism of the Organophosphate Pesticides Chlorpyrifos and Diazinon Characterizing the Influence of Structure and Route of Exposure on the Disposition of Dithiocarbamates Using Toluene-3,4-dithiol Analysis of Blood and Urinary Carbon Disulfide Metabolites Kinetic Modeling of β-Chloroprene Metabolism: I. In vitro Rates in Liver and Lung Tissue Fractions from Mice, Rats, Hamsters, and Humans Glutathione-Dependent Reduction of Arsenate in Human Erythrocytes—a Process Independent of Purine Nucleoside Phosphorylase Effect of Genetic Variation on Human Cytochrome P450 Reductase-Mediated Paraquat Cytotoxicity Absorption, Distribution, Metabolism, and Elimination of 8-2 Fluorotelomer Alcohol in the Rat Ginsenoside Metabolites, Rather Than Naturally Occurring Ginsenosides, Lead to Inhibition of Human Cytochrome P450 Enzymes Urinary Metabolites as Biomarkers of Acrylamide Exposure in Mice Following Dietary Crisp Bread Administration or Subcutaneous Injection The Effects of Dose, Route, and Repeated Dosing on the Disposition and Kinetics of Tetrabromobisphenol A in Male F-344 Rats Brain Uptake, Pharmacokinetics, and Tissue Distribution in the Rat of Neurotoxic N-Butylbenzenesulfonamide Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis in Male Fathead Minnows Exposed to 17α-Ethinylestradiol and 17β-Estradiol Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery” Characterization of Cellular Uptake of Perfluorooctanoate via Organic Anion-Transporting Polypeptide 1A2, Organic Anion Transporter 4, and Urate Transporter 1 for Their Potential Roles in Mediating Human Renal Reabsorption of Perfluorocarboxylates Use of Model-Based Compartmental Analysis to Study Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Vitamin A Kinetics in Rats Glucuronidation of Catechol Estrogens by Expressed Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7 Sex-Dependent Regulation of Hepatic Cytochrome P-450 by DDT Biotransformation and Kinetics of Excretion of tert-Amyl-methyl Ether in Humans and Rats after Inhalation Exposure Long Circulating Liposomes Encapsulating Organophosphorus Acid Anhydrolase in Diisopropylfluorophosphate Antagonism Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant Stress Increase in Bile Flow and Biliary Excretion of Glutathione-Derived Sulfhydryls in Rats by Drug-Metabolizing Enzyme Inducers Is Mediated by Multidrug Resistance Protein 2 Evaluation of Chronic Dietary Exposure to Indole-3-Carbinol and Absorption-Enhanced 3,3′-Diindolylmethane in Sprague-Dawley Rats Arsenate Reduction in Human Erythrocytes and Rats—Testing the Role of Purine Nucleoside Phosphorylase Xenobiotics Inhibit Hepatic Uptake and Biliary Excretion of Taurocholate in Rat Hepatocytes Inhibition of Human and Rat CYP1A2 by TCDD and Dioxin-like Chemicals Validation of Human Physiologically Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data Regulatory Mechanisms Modulating the Expression of Cytochrome P450 1A1 Gene by Heavy Metals Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury Acetaminophen Metabolism Does Not Contribute to Gender Difference in Its Hepatotoxicity in Mouse A Dermatotoxicokinetic Model of Human Exposures to Jet Fuel A Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Carbofuran in Sprague-Dawley Rats Using the Exposure-Related Dose Estimating Model Metabolomic Analyses of Body Fluids after Subchronic Manganese Inhalation in Rhesus Monkeys Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells HIGHLIGHT Biotransformation and Male Rat-Specific Renal Toxicity of Diethyl Ethyl- and Dimethyl Methylphosphonate Induction of Hepatic Microsomal Drug-Metabolizing Enzymes by Inhibitors of 5-Lipoxygenase (5-LO): Studies in Rats and 5-LO Knockout Mice Disposition of a Low Dose of Bisphenol A in Male and Female Cynomolgus Monkeys Dermal, Oral, and Inhalation Pharmacokinetics of Methyl Tertiary Butyl Ether (MTBE) in Human Volunteers Biotransformation of Methyl Parathion by Glutathione S-Transferases 1 TKB and ELA contributed equally to this study. 2 Current address: Department of Molecular Carcinogenesis, MD Anderson Cancer Center, Smithville, TX 78957. Analyses of Glutathione Reductase Hypomorphic Mice Indicate a Genetic Knockout Role of CYP2E1 in the Epoxidation of Acrylamide to Glycidamide and Formation of DNA and Hemoglobin Adducts Developmental Expression of Aldehyde Dehydrogenase in Rat: a Comparison of Liver and Lung Development A Single Oral Dose of Ethanol Can Alter Transdermal Absorption of Topically Applied Chemicals in Rats Phytochemicals Induce Breast Cancer Resistance Protein in Caco-2 Cells and Enhance the Transport of Benzo[a]pyrene-3-sulfate Induction of Cytochrome P450 1A1 by Ketoconazole and Itraconazole but not Fluconazole in Murine and Human Hepatoma Cell Lines Predicting Maternal Rat and Pup Exposures: How Different are They? Differential Effects of Polychlorinated Biphenyl Congeners on Serum Thyroid Hormone Levels in Rats In Vivo Percutaneous Absorption of Boric Acid, Borax, and Disodium Octaborate Tetrahydrate in Humans Compared to in Vitro Absorption in Human Skin from Infinite and Finite Doses Physiologically Based Pharmacokinetic Modeling of the Temperature-Dependent Dermal Absorption of Chloroform by Humans following Bath Water Exposures Hypochlorous Acid-Mediated Activation of N-acetylbenzidine to Form N′-(3′-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine Differential and Non-Uniform Tissue and Brain Distribution of Two Distinct 14C-Hexachlorobiphenyls in Weanling Rats Comparative Toxicokinetics of Manganese Chloride and Methylcyclopentadienyl Manganese Tricarbonyl (MMT) in Sprague-Dawley Rats Biliary and Urinary Excretion of Inorganic Arsenic: Monomethylarsonous Acid as a Major Biliary Metabolite in Rats Physiologically Based Pharmacokinetic Modeling of Inhalation Exposure of Humans to Dichloromethane during Moderate to Heavy Exercise Transplacental Exposure to Indole-3-carbinol Induces Sex-Specific Expression of CYP1A1 and CYP1B1 in the Liver of Fischer 344 Neonatal Rats A Biologically Based Dynamic Model for Predicting the Disposition of Methanol and Its Metabolites in Animals and Humans Reduction of Arsenate to Arsenite in Hepatic Cytosol Disposition of a Low Dose of 14C-Bisphenol A in Male Rats and Its Main Biliary Excretion as BPA Glucuronide Type 1 Diabetic Mice Are Protected from Acetaminophen Hepatotoxicity Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK Model Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans Adenovirus-Mediated Expression of CYP2E1 Produces Liver Toxicity in Mice Glutathione-Dependent Reduction of Arsenate by Glycogen Phosphorylase—Responsiveness to Endogenous and Xenobiotic Inhibitors Evaluating Transport of Manganese from Olfactory Mucosa to Striatum by Pharmacokinetic Modeling Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats Utility of Real Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling to Determine the Percutaneous Absorption of Methyl Chloroform in Rats and Humans Application of a Physiologically Based Pharmacokinetic Model to Estimate the Bioavailability of Ethanol in Male Rats: Distinction between Gastric and Hepatic Pathways of Metabolic Clearance Mu-Class GSTs Are Responsible for Aflatoxin B1-8,9-Epoxide-Conjugating Activity in the Nonhuman Primate Macaca fascicularis Liver Possible Relationship between Phototoxicity and Photodegradation of Sitafloxacin, a Quinolone Antibacterial Agent, in the Auricular Skin of Albino Mice Physiological Modeling Reveals Novel Pharmacokinetic Behavior for Inhaled Octamethylcyclotetrasiloxane in Rats Quantitative Evaluation of Urinary Porphyrins as a Measure of Kidney Mercury Content and Mercury Body Burden during Prolonged Methylmercury Exposure in Rats Physiological Modeling of the Relative Contributions of Styrene-7,8-oxide Derived from Direct Inhalation and from Styrene Metabolism to the Systemic Dose in Humans Expression and Activity of Microsomal Epoxide Hydrolase in Follicles Isolated from Mouse Ovaries Real-Time Polymerase Chain Reaction Analysis of CYP1B1 Gene Expression in Human Liver Correlation between Gene Expression of Aryl Hydrocarbon Receptor (AhR), Hydrocarbon Receptor Nuclear Translocator (Arnt), Cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and Inducibility of CYP1A1 and CYP1B1 in Human Lymphocytes Pharmacokinetics of Dibutylphthalate in Pregnant Rats Cloning, Tissue Expression, and Regulation of Beagle Dog CYP4A Genes Photochemotherapeutic Agent 8-Methoxypsoralen Induces Cytochrome P450 3A4 and Carboxylesterase HCE2: Evidence on an Involvement of the Pregnane X Receptor A Physiological Toxicokinetic Model for Inhaled Propylene Oxide in Rat and Human with Special Emphasis on the Nose Critical Role of PPAR-α in Perfluorooctanoic Acid- and Perfluorodecanoic Acid-Induced Downregulation of Oatp Uptake Transporters in Mouse Livers Mechanism of Ethylbenzene-Induced Mouse-Specific Lung Tumor: Metabolism of Ethylbenzene by Rat, Mouse, and Human Liver and Lung Microsomes

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