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Attributs	Valeurs
type	Concept
rdfs:label	DISCUSSION FORUM Discussion Forum
skos:inScheme	http://hub.abes.fr/referentiel/ouparticlecategories
is Subject of	The case for retention of mammalian cell mutagenicity assays An opinion on the significance of the 19 non-clastogenic gene-mutagens reported by Tennant et al. (1987) Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure The mouse lymphoma assay in the wake of ICH4—where are we now? Cell transformation: the role of oncogenes and factors The continuing search for an in vivo mutagen which is non-genotoxic in vitro-response to Tweats and Gatehouse: Letter to the Editor The short-term test activity profile for procarbazine hydrochloride: Letter to the Editor Sex differences in the micronucleus test: true or false? Is polyploidy an important genotoxic lesion? Further debate of testing strategies Prediction of chemical carcinogenicity from in vitro genetic toxicity Possible methodologies for the detection and study of DNA sequence changes following mutagen exposure: magnetic enrichment in mutant DNA Procarbazine is a potent mutagen at the heterozygous thymidine kinase (tk+/−) locus of mouse lymphoma assay Prospective ke screening of potential carcinogens being tested in rodent bioassays by the US National Toxicology Program p53 mutations, benzo[a]pyrene and lung cancer: a reply Treatment protocols for transgenic mutation assays in vivo Non-genotoxic carcinogenesis: implications for testing and extrapolation to man Is there evidence for directed mutation in bacteria? Sequence of centromere separation: a possible role for repetitive DNA Prediction of the carcinogenicity in rodents of chemicals currently being tested by the US National Toxicology Program: structure-activity correlations Oxidative metabolism of glutathione by γ-glutamyl transpeptidase and peroxisome proliferation: the relevance to hepatocarcinogenesis. A hypothesis Analysis of different versions of the IARC p53 database with respect to G→T transversion mutation frequencies and mutation hotspots in lung cancer of smokers and non-smokers A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program On clonal expansion and its effects on mutant frequencies, mutation spectra and statistics for somatic mutations in vivo Smoking, lung cancers and their TP53 mutations Slippage-misalignment: to what extent does it contribute to mammalian cell mutagenesis? Evaluation of potential mammalian genotoxins using Drosophila: the need for a change in test strategy The role of mammalian cell mutation assays in mutagenicity and carcinogenicity testing Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program Failure to adequately use positive control data leads to poor quality mouse lymphoma data assessments On the need for confirmation of negative genotoxicity results in vitro and on the usefulness of mammalian cell mutation tests in a core battery: experiences of a contract research laboratory The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens The inclusion of an assay for inherited congenital malformations in the assessment of mutagenicity Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results A mismatch repair-based model can explain some features of u.v. mutagenesis in yeast The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays - an in vivo equivalent dose concept Short-term tests and the myth of the non-clastogenic mutagen Environmental effects of genotoxins (eco-genotoxicology) Evaluating the ability of CASE, an artificial intelligence structure—activity relational system, to predict structural alerts for genotoxicity Prediction of probability of carcinogenicity for a set of ongoing NTP bioassays Does a genotoxic carcinogen contribute to human breast cancer?

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