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Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction
Metal-Catalyzed Phosphodiester Cleavage: Secondary 18OIsotope Effects as an Indicator of Mechanism
Examination of P−OR Bridging Bond Orders in PhosphateMonoesters using 18O Isotope Shifts in 31P NMR
Isotope Effects and Medium Effects on Sulfuryl Transfer Reactions
Isotope Effects on Enzyme-Catalyzed Acyl Transfer fromp-Nitrophenyl Acetate: Concerted Mechanisms and IncreasedHyperconjugation in the Transition State
Generality of Solvation Effects on the Hydrolysis Rates ofPhosphate Monoesters and Their Possible Relevance to EnzymaticCatalysis
A Mechanistic Study of the Alkaline Hydrolysis of Diaryl SulfateDiesters
Mutation of Arg-166 of Alkaline Phosphatase Alters the Thio Effect but Not theTransition State for Phosphoryl Transfer. Implications for the Interpretation of ThioEffects in Reactions of Phosphatases
An Altered Mechanism of Hydrolysis for a Metal-Complexed PhosphateDiester
Comparison of the Reaction Progress of Calcineurin with Mn2+ and Mg2+
Enzymatic Mechanisms of Phosphate and Sulfate Transfer
Does Positive Charge at the Active Sites of Phosphatases Cause aChange in Mechanism? The Effect of the Conserved Arginine on theTransition State for Phosphoryl Transfer in the Protein-TyrosinePhosphatase from Yersinia
Altered Mechanisms of Reactions of Phosphate EstersBridging a Dinuclear Metal Center
Mechanistic Study of Protein Phosphatase-1 (PP1), A Catalytically Promiscuous Enzyme
Mechanistic Studies of Protein Tyrosine Phosphatases YopH and Cdc25A withm-Nitrobenzyl Phosphate
Probing the Transition-State Structure of Dual-Specificity Protein PhosphatasesUsing a Physiological Substrate Mimic
Examination of the Transition State of the Low-Molecular Mass Small TyrosinePhosphatase 1. Comparisons with Other Protein Phosphatases
A Concerted Mechanism for the Transfer of theThiophosphinoyl Group from Aryl DimethylphosphinothioateEsters to Oxyanionic Nucleophiles in Aqueous Solution
Probing the Origin of the Compromised Catalysis of E. coliAlkaline Phosphatase in its Promiscuous Sulfatase Reaction
Isotope Effect Studies on the Calcineurin Phosphoryl-Transfer Reaction: TransitionState Structure and Effect of Calmodulin and Mn2+
Diesterase Activity and Substrate Binding in Purple Acid Phosphatases
The Thermodynamics of Phosphate versus PhosphorothioateEster Hydrolysis
Isotope Effects in the Study ofPhosphoryl and Sulfuryl TransferReactions
Transition-State Structures for the Native Dual-Specific Phosphatase VHR andD92N and S131A Mutants. Contributions to the Driving Force for Catalysis
Role of Protein Conformational Mobility in Enzyme Catalysis: Acylation ofα-Chymotrypsin by Specific Peptide Substrates
Heavy-Atom Isotope Effects on Reactions of Co(III)-Boundp-Nitrophenyl Phosphate: Nucleophilic Displacements ofp-Nitrophenol and Dissociation of p-Nitrophenyl Phosphate
Kinetic Isotope Effects for Acyl Transfer from p-NitrophenylAcetate to Hydroxylamine Show a pH-Dependent Change inMechanism
Transition State Differences in Hydrolysis Reactionsof Alkyl versus Aryl Phosphate Monoester Monoanions [J. Am. Chem. Soc.2003, 125, 13106−13111].
Altered Transition State for the Reaction of an RNA Model Catalyzed by a Dinuclear Zinc(II) Catalyst
18O Isotope Effects Support a ConcertedMechanism for Ribonuclease A
The Transition State of the Phosphoryl-Transfer Reaction Catalyzedby the Lambda Ser/Thr Protein Phosphatase
Effects on General Acid Catalysis from Mutations of the Invariant Tryptophan andArginine Residues in the Protein Tyrosine Phosphatase from Yersinia
Characterization of Transition States inDichloro(1,4,7-triazacyclononane)copper(II)-Catalyzed ActivatedPhosphate Diester Hydrolysis
Comparisons of Phosphorothioate with Phosphate TransferReactions for a Monoester, Diester, and Triester: IsotopeEffect Studies
Kinetic Isotope Effects for Alkaline Phosphatase Reactions: Implications for the Role of Active-Site Metal Ions in Catalysis
Transition State Analysis and Requirement of Asp-262 General Acid/Base Catalystfor Full Activation of Dual-Specificity Phosphatase MKP3 by ExtracellularRegulated Kinase
Transesterification Thio Effects of Phosphate Diesters: Free Energy Barriers andKinetic and Equilibrium Isotope Effects from Density-Functional Theory
Probing Potential Medium Effects on Phosphate Ester BondsUsing 18O Isotope Shifts on 31P NMR
Thermodynamic Origin of the Increased Rate of Hydrolysis ofPhosphate and Phosphorothioate Esters in DMSO/Water Mixtures
The Effects of Sulfur Substitution for the Nucleophile and Bridging Oxygen Atoms in Reactions of Hydroxyalkyl Phosphate Esters
A Comparison of Phosphonothioic Acids with Phosphonic Acids asPhosphatase Inhibitors
Comparisons of Phosphorothioate and Phosphate Monoester TransferReactions: Activation Parameters, Solvent Effects, and the Effect ofMetal Ions
Transition State Differences in Hydrolysis Reactions of Alkylversus Aryl Phosphate Monoester Monoanions
Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes
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