About: Penning Trevor M.

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Attributs	Valeurs
type	Person
name	Penning Trevor M.
personal mailbox	penning@pharm.med.upenn.edu
familyName	Penning
Given name	T. M. Trevor M.
is relates of	http://hub.abes.fr/acs/periodical/crtoec/1993/volume_6/issue_3/101021tx00033a002/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/1998/volume_37/issue_27/101021bi980294p/authorship/2 http://hub.abes.fr/acs/periodical/bichaw/2004/volume_43/issue_19/101021bi0499563/authorship/5 http://hub.abes.fr/acs/periodical/bichaw/1994/volume_33/issue_34/101021bi00200a017/authorship/6 http://hub.abes.fr/acs/periodical/bcches/1992/volume_3/issue_3/101021bc00015a003/authorship/2 http://hub.abes.fr/acs/periodical/bichaw/1989/volume_28/issue_10/101021bi00436a057/authorship/1 http://hub.abes.fr/oup/periodical/carcin/1992/volume_13/issue_9/101093carcin1391575/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/1999/volume_38/issue_24/101021bi982838t/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/2005/volume_18/issue_2/101021tx0497245/authorship/4 http://hub.abes.fr/acs/periodical/bichaw/1998/volume_37/issue_31/101021bi980475r/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/2006/volume_45/issue_43/101021bi060591r/authorship/2 http://hub.abes.fr/acs/periodical/crtoec/2007/volume_20/issue_3/101021tx060180b/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/2008/volume_21/issue_5/101021tx700345v/authorship/2 http://hub.abes.fr/acs/periodical/jnprdf/2004/volume_67/issue_11/101021np0498410/authorship/2 http://hub.abes.fr/acs/periodical/joceah/2008/volume_73/issue_3/101021jo701667u/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2006/volume_19/issue_1/101021tx0502488/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2008/volume_21/issue_11/101021tx8002005/authorship/3 http://hub.abes.fr/oup/periodical/toxsci/2005/volume_87/issue_2/101093toxscikfi265/authorship/5 http://hub.abes.fr/oup/periodical/carcin/1995/volume_16/issue_11/101093carcin16112707/authorship/3 http://hub.abes.fr/oup/periodical/carcin/1990/volume_11/issue_7/101093carcin1171203/authorship/1 http://hub.abes.fr/oup/periodical/carcin/1993/volume_14/issue_3/101093carcin143475/authorship/3 http://hub.abes.fr/oup/periodical/carcin/2009/volume_30/issue_9/101093carcinbgp176/authorship/5 http://hub.abes.fr/oup/periodical/humupd/2003/volume_9/issue_3/101093humupddmg022/authorship/1 http://hub.abes.fr/acs/periodical/bichaw/1998/volume_37/issue_19/101021bi972725u/authorship/3 http://hub.abes.fr/acs/periodical/joceah/2004/volume_69/issue_6/101021jo030348n/authorship/4 http://hub.abes.fr/acs/periodical/jnprdf/2005/volume_68/issue_1/101021np049702i/authorship/4 http://hub.abes.fr/acs/periodical/bichaw/2001/volume_40/issue_36/101021bi010872t/authorship/4 http://hub.abes.fr/acs/periodical/bichaw/2002/volume_41/issue_39/101021bi020270p/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2000/volume_13/issue_3/101021tx9902082/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/1997/volume_36/issue_24/101021bi962750k/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/1999/volume_12/issue_1/101021tx980143n/authorship/1 http://hub.abes.fr/acs/periodical/crtoec/1996/volume_9/issue_1/101021tx950055s/authorship/1 http://hub.abes.fr/acs/periodical/crtoec/2006/volume_19/issue_11/101021tx0601206/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2002/volume_15/issue_6/101021tx010177m/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/2001/volume_40/issue_34/101021bi010919a/authorship/5 http://hub.abes.fr/acs/periodical/bichaw/2000/volume_39/issue_1/101021bi991659o/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/1999/volume_12/issue_3/101021tx980182z/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2005/volume_18/issue_6/101021tx050001a/authorship/6 http://hub.abes.fr/acs/periodical/crtoec/2008/volume_21/issue_3/101021tx7003695/authorship/6 http://hub.abes.fr/acs/periodical/bichaw/1996/volume_35/issue_42/101021bi961077w/authorship/5 http://hub.abes.fr/acs/periodical/crtoec/2001/volume_14/issue_7/101021tx0100035/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/1996/volume_35/issue_33/101021bi9604688/authorship/4 http://hub.abes.fr/acs/periodical/bichaw/1999/volume_38/issue_32/101021bi995085z/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/2008/volume_21/issue_5/101021tx700404a/authorship/9 http://hub.abes.fr/acs/periodical/bichaw/1997/volume_36/issue_28/101021bi970367p/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/1998/volume_37/issue_10/101021bi9723055/authorship/3 http://hub.abes.fr/acs/periodical/bichaw/2004/volume_43/issue_38/101021bi0489762/authorship/2 http://hub.abes.fr/acs/periodical/chreay/2001/volume_101/issue_10/101021cr000049n/authorship/1 http://hub.abes.fr/acs/periodical/crtoec/2006/volume_19/issue_5/101021tx0600245/authorship/4 http://hub.abes.fr/acs/periodical/crtoec/2007/volume_20/issue_9/101021tx700107z/authorship/6 http://hub.abes.fr/acs/periodical/bichaw/1991/volume_30/issue_49/101021bi00113a010/authorship/2 http://hub.abes.fr/acs/periodical/bichaw/1995/volume_34/issue_3/101021bi00003a014/authorship/3 http://hub.abes.fr/springer/periodical/11/1991/volume_34/issue_1_2/B958C0187C78573EE053120B220A00F7/authorship/3 http://hub.abes.fr/acs/periodical/crtoec/1992/volume_5/issue_4/101021tx00028a018/authorship/3
is Author of	Secosteroid Mechanism-Based Inactivators and Site-Directed Mutagenesis as Probes for Steroid Hormone Recognition by 3.alpha.-Hydroxysteroid Dehydrogenase Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3.alpha.-hydroxysteroid dehydrogenase Bromoacetamido Analogs of Indomethacin and Mefenamic Acid as Affinity-Labeling Agents and Mechanistic Probes for Prostaglandin H2 Synthase Characterization of dihydrodiol dehydrdrogenase in human liver and lung Multiple Steps Determine the Overall Rate of the Reduction of5α-Dihydrotestosterone Catalyzed by Human Type 3 3α-HydroxysteroidDehydrogenase: Implications for the Elimination of Androgens Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes Dihydrodiol Dehydrogenases and Polycyclic AromaticHydrocarbon Activation: Generation of Reactive andRedox Active o-Quinones Aldo−Keto Reductase- and Cytochrome P450-Dependent Formationof Benzo[a]pyrene-Derived DNA Adducts in HumanBronchoalveolar Cells Viniferin Formation by COX-1: Evidence for Radical Intermediates duringCo-oxidation of Resveratrol The Arginine 276 Anchor for NADP(H) Dictates Fluorescence Kinetic Transients in3α-Hydroxysteroid Dehydrogenase, a Representative Aldo−Keto Reductase Crystal Structure of Human Type III 3α-Hydroxysteroid Dehydrogenase/Bile AcidBinding Protein Complexed with NADP+ and Ursodeoxycholate, DNA Strand Scission by Polycyclic Aromatic Hydrocarbon o-Quinones: Role ofReactive Oxygen Species, Cu(II)/Cu(I) Redox Cycling, and o-Semiquinone AnionRadicals, Mutagenesis of 3α-Hydroxysteroid Dehydrogenase Reveals a “Push−Pull”Mechanism for Proton Transfer in Aldo−Keto Reductases Mutation of Nicotinamide Pocket Residues in Rat Liver 3α-HydroxysteroidDehydrogenase Reveals Different Modes of Cofactor Binding The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogentrans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic AromaticHydrocarbon Activation Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts Contribution of dihydrodiol dehydrogenase to the metabolism of (±)-trans;-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions Expression and Characterization of Four Recombinant Human DihydrodiolDehydrogenase Isoforms: Oxidation oftrans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-QuinoneMetabolite Benzo[a]pyrene-7,8-dione, Engineering Steroid 5β-Reductase Activity into Rat Liver 3α-HydroxysteroidDehydrogenase Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation oftrans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action Ryanodine Receptor-Mediated Rapid Increase in Intracellular Calcium Induced by 7,8-Benzo(a)Pyrene Quinone in Human and Murine Leukocytes Formation of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine(8-Oxo-dGuo) by PAH o-Quinones: Involvement ofReactive Oxygen Species and Copper(II)/Copper(I)Redox Cycling Alanine Scanning Mutagenesis of the Testosterone Binding Site of Rat3α-Hydroxysteroid Dehydrogenase Demonstrates Contact Residues Influence theRate-Determining Step Synthesis and Characterization of Polycyclic AromaticHydrocarbon o-Quinone Depurinating N7-GuanineAdducts Competing Roles of Aldo-Keto Reductase 1A1 and CytochromeP4501B1 in Benzo[a]pyrene-7,8-diol Activation in HumanBronchoalveolar H358 Cells: Role of AKRs in P4501B1 Induction Structure of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Complexed withNADP+ Comparison of p53 Mutations Induced by PAH o-Quinones withThose Caused by anti-Benzo[a]pyrene Diol Epoxide in Vitro: Roleof Reactive Oxygen and Biological Selection Oxidation of PAH trans-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10 Synthesis of the o-Quinones and Other Oxidized Metabolites ofPolycyclic Aromatic Hydrocarbons Implicated in Carcinogenesis Dissection of the Physiological Interconversion of 5α-DHT and 3α-Diol by Rat3α-HSD via Transient Kinetics Shows That the Chemical Step IsRate-Determining: Effect of Mutating Cofactor and Substrate-Binding PocketResidues on Catalysis Enzyme Redesign Retention of NADPH-Linked Quinone Reductase Activity in an Aldo-KetoReductase Following Mutation of the Catalytic Tyrosine Reactive Oxygen Species Generated by PAH o-QuinonesCause Change-In-Function Mutations in p53 Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography-Mass Spectrometry Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A GenotoxicMetabolite Generated by Dihydrodiol Dehydrogenase,

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