This HTML5 document contains 33 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Subject Item

n2:w

rdf:type

bibo:Article rdac:C10001

dcterms:isPartOf

n16:w

dcterms:subject

n12:cholecystokinin n12:chronicpancreatitis n12:exocrinepancreaticfunction n12:pancreaticpolypeptide n12:gallbladderemptying

hub:subTitle

Relationship to exocrine pancreatic function, CCK, and PP release

dcterms:title

Gallbladder dynamics in chronic pancreatitis

rdaw:P10072

n4:print n4:web

vivo:relatedBy

n6:2 n6:6 n6:3 n6:5 n6:7 n6:4 n6:1

marcrel:aut

n2:ditschuneith n2:rieplr n2:friessh n2:klatts n17:id n2:glasbrennerb n2:pieramicoo

dcterms:abstract

Abstract. Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide intravenous infusion (2.5 ng/kg/min for 10 min). On day 2, a mixed standard test meal (1450 kJ) was administered orally. Gallbladder volume was assessed at three time intervals before (−30, −15, 0 min) and at 5, 10, 20, 30, 40, 50, 60, 80, 100 and 120 min after stimulation by means of ultrasonography. CCK and PP plasma levels were determined at each time interval.Exocrine pancreatic function was assessed using the pancreolauryl serum test (PLT). Six patients with CP had severe exocrine pancreatic insufficiency (EPI) (PLT<1.8 μg/ml) with steatorrhea, eight patients had mild-moderate EPI. Fasting gallbladder volume was increased in CP (32.3±3.1 cm3) as compared to controls (20.5±1.2 cm3) (P<0.01). Peak gallbladder contraction (percent of initial volume) in CP ranged from 5 to 55% (controls: 8-46%) following ceruletide and from 17 to 86% (controls: 27-80%) following the test meal (NS). There was no correlation between the degree of EPI according to PLT and peak gallbladder contraction. Gallbladder emptying in CP patients was not different from controls, although the postprandial CCK response was significantly impaired (P<0.01). Postprandial PP response in CP was correlated with the PLT result (r=0.78;P<0.01) but not with gallbladder emptying or refilling time. We conclude that gallbladder emptying and refilling following the oral administration of a test meal or the stimulation with a pharmacological dose of ceruletide is normal in patients with chronic pancreatitis. Postprandial gallbladder emptying is not influenced by the degree of exocrine pancreatic insufficiency.

hub:articleType

n10:originalarticles n18:originalpaper

hub:publisher-id

BF01316503

dcterms:dateCopyrighted

1993

dcterms:rightsHolder

n15:plenumpublishingcorporation

hub:isPartOfThisJournal

n9:w